Literature DB >> 7379935

Inhibition of sterol biosynthesis by 14 alpha-hydroxy-delta 7-sterols.

G J Schroepfer, R A Pascal, A A Kandutsch.   

Abstract

5 alpha-Cholest-7-en-3 beta, 14 alpha-diol and 5 alpha-cholest-7-en-14 alpha-ol-3-one have been found to be potent inhibitors of the synthesis of digitonin-precipitable sterols in L cells in culture and to reduce the levels of HMG-CoA reductase activity in these cells.

Entities:  

Mesh：

Substances：

Year:  1980        PMID： 7379935     DOI： 10.1007/bf01965773

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  13 in total

1.  14alpha-ethyl-5alpha-cholest-7-ene-3beta,15alpha-diol, an extraodinarily potent inhibitor of sterol biosynthesis in animal cells.

Authors:  G J Schroepfer; E J Parich; A A Kandutsch
Journal:  J Am Chem Soc       Date:  1977-08-03       Impact factor: 15.419

2.  Inactive 3-hydroxy-3-methylglutaryl-coenzyme A reductase in broken cell preparations of various mammalian tissues and cell cultures.

Authors:  S E Saucier; A A Kandutsch
Journal:  Biochim Biophys Acta       Date:  1979-03-29

3.  Inhibition of sterol synthesis in cultured mouse cells by cholesterol derivatives oxygenated in the side chain.

Authors:  A A Kandutsch; H W Chen
Journal:  J Biol Chem       Date:  1974-10-10       Impact factor: 5.157

4.  Sterol synthesis. Chemical synthesis of 5 alpha-cholest-7-en-3 beta, 14 alpha-diol.

Authors:  R A Pascal; G J Schroepfer
Journal:  J Lipid Res       Date:  1980-01       Impact factor: 5.922

5.  Inhibition of sterol biosynthesis in animal cells by 14 alpha-alkyl-substituted 15-oxygenated sterols.

Authors:  G J Schroepfer; E J Parish; M Tsuda; D L Raulston; A A Kandutsch
Journal:  J Lipid Res       Date:  1979-11       Impact factor: 5.922

6.  Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in human fibroblasts by lipoproteins.

Authors:  M S Brown; S E Dana; J L Goldstein
Journal:  Proc Natl Acad Sci U S A       Date:  1973-07       Impact factor: 11.205

7.  Biological activity of some oxygenated sterols.

Authors:  A A Kandutsch; H W Chen; H J Heiniger
Journal:  Science       Date:  1978-08-11       Impact factor: 47.728

8.  Inhibition of sterol synthesis in animal cells by 15-oxygenated sterols with the unnatural cis-C-D ring junction-"5alpha,14beta-cholest-7-en-15alpha-ol-3-one and 5alpha,14beta-cholest-7-en-15beta-ol-3-one.

Authors:  G J Schroepfer; R A Pascal; A A Kandutsch
Journal:  Biochem Pharmacol       Date:  1979       Impact factor: 5.858

9.  Relationship between sterol synthesis and DNA synthesis in phytohemagglutinin-stimulated mouse lymphocytes.

Authors:  H W Chen; H J Heiniger; A A Kandutsch
Journal:  Proc Natl Acad Sci U S A       Date:  1975-05       Impact factor: 11.205

10.  Inhibition of sterol synthesis in cultured mouse cells by 7alpha-hydroxycholesterol, 7beta-hydroxycholesterol, and 7-ketocholesterol.

Authors:  A A Kandutsch; H W Chen
Journal:  J Biol Chem       Date:  1973-12-25       Impact factor: 5.157
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.