Literature DB >> 7379906

Structure and toxicity of the alkaloids of Russian comfrey (symphytum x uplandicum Nyman), a medicinal herb and item of human diet.

C C Culvenor, M Clarke, J A Edgar, J L Frahn, M V Jago, J E Peterson, L W Smith.   

Abstract

Eight pyrrolizidine alkaloids of hepatotoxic type have been indentified in leaves of Symphytum X uplandicum. The combined alkaloids exhibit chronic hepatotoxicity in rats.

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Year:  1980        PMID： 7379906     DOI： 10.1007/bf01975096

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  13 in total

1.  Liver lesions in young rats suckled by mothers treated with the pyrrolizidine (Senecio) alkaloids, lasiocarpine and retrorsine.

Authors:  R SCHOENTAL
Journal:  J Pathol Bacteriol       Date:  1959-04

2.  Crotalaria Retusa poisoning of pigs and poultry.

Authors:  P T Hooper; W A Scanlan
Journal:  Aust Vet J       Date:  1977-03       Impact factor: 1.281

3.  Islet cell tumors of the pancreas found in rats given pyrrolizidine alkaloids from Amsinckia intermedia Fisch and Mey and from Heliotropium supinum L.

Authors:  R Schoental; M E Fowler; A Coady
Journal:  Cancer Res       Date:  1970-08       Impact factor: 12.701

Review 4.  The toxic actions of pyrrolizidine (senecio) alkaloids.

Authors:  E K McLean
Journal:  Pharmacol Rev       Date:  1970-12       Impact factor: 25.468

5.  A method for the assessment of the chronic hepatoxicity of pyrrolizidine alkaloids.

Authors:  M V Jago
Journal:  Aust J Exp Biol Med Sci       Date:  1970-02

6.  An epidemic of veno-occlusive disease of liver in central India.

Authors:  B N Tandon; H D Tandon; R K Tandon; M Narndranathan; Y K Joshi
Journal:  Lancet       Date:  1976-08-07       Impact factor: 79.321

7.  Hepato- and pneumotoxicity of pyrrolizidine alkaloids and derivatives in relation to molecular structure.

Authors:  C C Culvenor; J A Edgar; M V Jago; A Qutteridge; J E Peterson; L W Smith
Journal:  Chem Biol Interact       Date:  1976-03       Impact factor: 5.192

8.  The photometric microdetermination of serum total globulins with a tryptophan reaction: a modified procedure.

Authors:  A Saifer; T Marven
Journal:  Clin Chem       Date:  1966-07       Impact factor: 8.327

9.  Bioassay of lasiocarpine for possible carcinogenicity.

Authors: 
Journal:  Natl Cancer Inst Carcinog Tech Rep Ser       Date:  1978

10.  Carcinogenic activity of Symphytum officinale.

Authors:  I Hirono; H Mori; M Haga
Journal:  J Natl Cancer Inst       Date:  1978-09       Impact factor: 13.506
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  3 in total

Review 1.  The harmful potential of herbal and other plant products.

Authors:  R J Huxtable
Journal:  Drug Saf       Date:  1990       Impact factor: 5.606

2.  Pyrrolizidine alkaloids from Symphytum officinale L. and their percutaneous absorption in rats.

Authors:  J Brauchli; J Lüthy; U Zweifel; C Schlatter
Journal:  Experientia       Date:  1982-09-15

3.  Epidemiologic survey on lung cancer with respect to cigarette smoking and plant diet.

Authors:  R Sakai
Journal:  Jpn J Cancer Res       Date:  1989-06
  3 in total

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