Literature DB >> 7378069

Interactions between vasopressin and glucagon on ketogenesis and oleate metabolism in isolated hepatocytes from fed rats.

D H Williamson, V Ilic, A F Tordoff, E V Ellington.   

Abstract

Vasopressin (10nM) inhibited ketogenesis (56%) in hepatocytes from fed rats when oleate (1 mM) was the substrate, but had no effect with butyrate (10mM). The hormone increased the accumulation of lactate and stimulated the esterification of [1(-14)C]oleate (70%). These effects of vasopressin were reversed by glucagon (10 nM). The physiological implications of these findings are discussed.

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Year:  1980        PMID： 7378069      PMCID： PMC1161618          DOI： 10.1042/bj1860621

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  26 in total

1.  Studies on the inhibition of hepatic lipogenesis by N-6,O-2'-dibutyryl adenosine 3',5'-monophosphate.

Authors:  R A Harris
Journal:  Arch Biochem Biophys       Date:  1975-07       Impact factor: 4.013

2.  The activation of liver glycogen phosphorylase by vasopressin.

Authors:  S Keppens; H de Wulf
Journal:  FEBS Lett       Date:  1975-03-01       Impact factor: 4.124

3.  Effect of glucagon on hepatic malonyl coenzyme A concentration and on lipid synthesis.

Authors:  G A Cook; R C Nielsen; R A Hawkins; M A Mehlman; M R Lakshmanan; R L Veech
Journal:  J Biol Chem       Date:  1977-06-25       Impact factor: 5.157

4.  Effects of lactation of ketogenesis from oleate or butyrate in rat hepatocytes.

Authors:  E Whitelaw; D H Williamson
Journal:  Biochem J       Date:  1977-06-15       Impact factor: 3.857

5.  Control of gluconeogenesis in liver. II. Effects of glucagon, catecholamines, and adenosine 3',5'-monophosphate on gluconeogenesis in the perfused rat liver.

Authors:  J H Exton; C R Park
Journal:  J Biol Chem       Date:  1968-08-25       Impact factor: 5.157

6.  Branched-chain amino acids, nitrogen excretion and injury in man.

Authors:  J H Wedge; R De Campos; A Kerr; R Smith; R Farrell; V Ilic; D H Williamson
Journal:  Clin Sci Mol Med       Date:  1976-05

7.  Inhibition of fatty acid synthesis and stimulation of glycogen breakdown by vasopressin in the perfused mouse liver.

Authors:  G Y Ma; D A Hems
Journal:  Biochem J       Date:  1975-11       Impact factor: 3.857

8.  Metabolic actions of vasopressin, glucagon and adrenalin in the intact rat.

Authors:  D A Hems; P D Whitton; G Y Ma
Journal:  Biochim Biophys Acta       Date:  1975-11-10

9.  Vasopressin clearance and secretion during haemorrhage in normal dogs and in dogs with experimental diabetes insipidus.

Authors:  M L Errington; M Rocha e Silva
Journal:  J Physiol       Date:  1972-12       Impact factor: 5.182

10.  High-yield preparation of isolated rat liver parenchymal cells: a biochemical and fine structural study.

Authors:  M N Berry; D S Friend
Journal:  J Cell Biol       Date:  1969-12       Impact factor: 10.539
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  16 in total

1.  Distinct effects of glucagon and vasopressin on proline metabolism in isolated hepatocytes. The role of oxoglutarate dehydrogenase.

Authors:  J M Staddon; J D McGivan
Journal:  Biochem J       Date:  1984-01-15       Impact factor: 3.857

2.  Effects of phorbol esters, A23187 and vasopressin on oleate metabolism in isolated rat hepatocytes.

Authors:  T Nomura; M Tachibana; H Nomura; M Chihara; Y Hagino
Journal:  Lipids       Date:  1987-07       Impact factor: 1.880

3.  The effects of orthovanadate on fatty acid synthesis in isolated rat hepatocytes.

Authors:  L Agius; W J Vaartjes
Journal:  Biochem J       Date:  1982-03-15       Impact factor: 3.857

4.  Stimulation of hepatic lipogenesis and acetyl-coenzyme A carboxylase by vasopressin.

Authors:  F Assimacopoulos-Jeannet; R M Denton; B Jeanrenaud
Journal:  Biochem J       Date:  1981-09-15       Impact factor: 3.857

5.  Effects of vasopressin and corticosterone on fatty acid metabolism and on the activities of glycerol phosphate acyltransferase and phosphatidate phosphohydrolase in rat hepatocytes.

Authors:  A D Pollard; D N Brindley
Journal:  Biochem J       Date:  1984-01-15       Impact factor: 3.857

6.  Role of glycerol 3-phosphate and glycerophosphate acyltransferase in the nutritional control of hepatic triacylglycerol synthesis.

Authors:  P E Declercq; L J Debeer; G P Mannaerts
Journal:  Biochem J       Date:  1982-04-15       Impact factor: 3.857

7.  Glucagon inhibits triacylglycerol synthesis in isolated hepatocytes by lowering their glycerol 3-phosphate content.

Authors:  P E Declercq; L J Debeer; G P Mannaerts
Journal:  Biochem J       Date:  1982-03-15       Impact factor: 3.857

8.  Mechanism for the 'anti-lipolytic' action of vasopressin in the starved rat.

Authors:  A M Rofe; D H Williamson
Journal:  Biochem J       Date:  1983-06-15       Impact factor: 3.857

9.  Metabolic effects of vasopressin infusion in the starved rat. Reversal of ketonaemia.

Authors:  A M Rofe; D H Williamson
Journal:  Biochem J       Date:  1983-04-15       Impact factor: 3.857

10.  The activation of Na+-dependent efflux of Ca2+ from liver mitochondria by glucagon and beta-adrenergic agonists.

Authors:  T P Goldstone; R J Duddridge; M Crompton
Journal:  Biochem J       Date:  1983-02-15       Impact factor: 3.857
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