Literature DB >> 7377861

Levamisole-associated neutropenia and autoimmune granulocytotoxins.

S I Drew, B M Carter, D S Nathanson, P I Terasaki.   

Abstract

To investigate possible immune mechanisms responsible for levamisole-associated neutropenia we tested patients with bladder cancer on levamisole therapy. Autoimmune and complement-dependent granulocytotoxic antibodies were detected in 3 patients with levamisole-induced neutropenia. The granulocytopenia appeared to be causally related to the presence of autoantibodies in that pretreatment serum or serum obtained after the restoration of neutrophil counts showed diminished or no granulocytotoxic reactivity. In addition, granulocytotoxins were found in 6 out of 20 (30%) patients receiving levamisole compared to only 2 out of 28 (7.1%) patients on no levamisole or placebo (P less than 0.06). Hence, screening for granulocytotoxins may forewarn of neutropenia in patients receiving levamisole for a variety of clinical diseases.

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Year:  1980        PMID： 7377861      PMCID： PMC1000471          DOI： 10.1136/ard.39.1.59

Source DB:  PubMed          Journal:  Ann Rheum Dis        ISSN： 0003-4967            Impact factor:   19.103


  10 in total

Review 1.  Levamisole in the modulation of the immune response: the current experimental and clinical state.

Authors:  J Symoens; M Rosenthal
Journal:  J Reticuloendothel Soc       Date:  1977-03

Review 2.  Immune and toxic mechanisms in drug-induced agranulocytosis.

Authors:  A V Pisciotta
Journal:  Semin Hematol       Date:  1973-10       Impact factor: 3.851

3.  Serotyping for homotransplantation. 18. Refinement of microdroplet lymphocyte cytotoxicity test.

Authors:  K K Mittal; M R Mickey; D P Singal; P I Terasaki
Journal:  Transplantation       Date:  1968-11       Impact factor: 4.939

Review 4.  Clinical significance of leukocyte iso- and auto-antibodies.

Authors:  P Lalezari
Journal:  Semin Hematol       Date:  1966-01       Impact factor: 3.851

5.  Levamisole and agranulocytosis.

Authors:  M Rosenthal; Y Breysse; A S Dixon; P Franchimont; E C Huskisson; K L Schmidt; E Schuermans Y Veys; T L Vischer; P A Janssen; J Brugmans; J de CREPE; J Symoens; A L Macnair; W K Amery; E Veys
Journal:  Lancet       Date:  1977-04-23       Impact factor: 79.321

6.  Antigenic specificities detected on papainized human granulocytes by microgranulocytotoxicity.

Authors:  S I Drew; O Bergh; J McClelland; R Mickey; P I Terasaki
Journal:  Transplant Proc       Date:  1977-03       Impact factor: 1.066

7.  Letter: Leucocytotoxic effect of levamisole.

Authors:  M Rosenthal; U Trabert; W Müller
Journal:  Lancet       Date:  1976-02-14       Impact factor: 79.321

8.  Cell surface antigens detected on mature and leukemic granulocytic populations by cytotoxicity testing.

Authors:  S I Drew; B M Carter; P I Terasaki; F Naiem; D S Nathanson; B Abromowitz; R P Gale
Journal:  Tissue Antigens       Date:  1978-08

9.  Complications of cancer immunotherapy with levamisole.

Authors:  D R Parkinson; P O Cano; L M Jerry; A Capek; H R Shibata; P W Mansell; M G Lewis; G Marquis
Journal:  Lancet       Date:  1977-05-28       Impact factor: 79.321

10.  Lymphocytotoxic antibodies in family members of patients with multiple sclerosis.

Authors:  A L Schocket; H L Weiner
Journal:  Lancet       Date:  1978-03-18       Impact factor: 79.321
  10 in total
  6 in total

1.  Inhibition of suppressor T cells in pokeweed mitogen-stimulated cultures of T and B cells by levamisole in vitro and in vivo.

Authors:  P Hersey; K Ho; J Werkmeister; U Abele
Journal:  Clin Exp Immunol       Date:  1981-11       Impact factor: 4.330

2.  HLA-B27-mediated activation of TNAP phosphatase promotes pathogenic syndesmophyte formation in ankylosing spondylitis.

Authors:  Chin-Hsiu Liu; Sengupta Raj; Chun-Hsiung Chen; Kuo-Hsuan Hung; Chung-Tei Chou; Ing-Ho Chen; Jui-Teng Chien; I-Ying Lin; Shii-Yi Yang; Takashi Angata; Wen-Chan Tsai; James Cheng-Chung Wei; I-Shiang Tzeng; Shih-Chieh Hung; Kuo-I Lin
Journal:  J Clin Invest       Date:  2019-12-02       Impact factor: 14.808

3.  Levamisole-induced occlusive necrotising vasculitis in cocaine abusers: an unusual cause of skin necrosis and neutropenia.

Authors:  Cassius D Belfonte; Victoria K Shanmugam; Nicole Kieffer; Shodeinde Coker; Suelyn Boucree; Gail Kerr
Journal:  Int Wound J       Date:  2012-06-21       Impact factor: 3.315

4.  [Granulocytotoxic antibodies in levamisole-induced agranulocytosis].

Authors:  M Rosenthal
Journal:  Klin Wochenschr       Date:  1982-10-15

5.  Recurrent febrile neutropenia and thrombocytopenia in a chronic cocaine user: a case of levamisole induced complications.

Authors:  Eduardo Martinez; Raza Alvi; Sindhaghatta Venkatram; Gilda Diaz-Fuentes
Journal:  Case Rep Crit Care       Date:  2015-03-22

6.  Levamisole tainted cocaine causing severe neutropenia in Alberta and British Columbia.

Authors:  Lewinda Knowles; Jane A Buxton; Nataliya Skuridina; Ifeoma Achebe; Donald Legatt; Shihe Fan; Nancy Yan Zhu; James Talbot
Journal:  Harm Reduct J       Date:  2009-11-17
  6 in total

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