Literature DB >> 7375496

Effect of serotonin on Y-maze retention and hippocampal protein synthesis in rats.

W Wetzel, V M Getsova, R Jork, H Matthies.   

Abstract

The effect of serotonin (5-HT) on consolidation of a brightness discrimination reaction was investigated in rats. Five microgram 5-HT, injected intrahippocampally immediately after training, impaired retention of the brightness discrimination tested 24 hr later. In biochemical experiments, leucine incorporation into hippocampal proteins in vivo was 32% inhibited by 5 microgram 5-HT. Leucine incorporation into proteins of hippocampal slices in vitro was decreased by 5 x 10(-5)M 5-HT. The results seem to support Essman's assumption that inhibition of brain protein synthesis by 5-HT may be responsible for the memory impairment. But also some other possibilities for a mechanism of 5-HT amnesia must be discussed.

Entities:  

Mesh：

Substances：

Year:  1980        PMID： 7375496     DOI： 10.1016/0091-3057(80)90378-0

Source DB:  PubMed          Journal:  Pharmacol Biochem Behav        ISSN： 0091-3057            Impact factor:   3.533


  11 in total

1.  Evidence for a possible interaction between noradrenergic and serotonergic neurotransmission in the retrieval of a previously learned aversive habit in mice.

Authors:  H J Normile; H J Altman
Journal:  Psychopharmacology (Berl)       Date:  1987       Impact factor: 4.530

2.  Enhancement of the memory of a previously learned aversive habit following pre-test administration of a variety of serotonergic antagonists in mice.

Authors:  H J Altman; H J Normile
Journal:  Psychopharmacology (Berl)       Date:  1986       Impact factor: 4.530

3.  Postischemic breakdown in hippocampal protein synthesis and mnesic deficits in rats: pharmacological improvement by curative naftidrofuryl treatment.

Authors:  Y Lamproglou; M Le Poncin; W Jacques; N Wiernsperger; J R Rapin
Journal:  Metab Brain Dis       Date:  1992-12       Impact factor: 3.584

4.  Strain-dependent effects of cocaine on memory storage improvement induced by post-training physostigmine.

Authors:  C Castellano; A Zocchi; S Cabib; S Puglisi-Allegra
Journal:  Psychopharmacology (Berl)       Date:  1996-02       Impact factor: 4.530

5.  A specific role for group I mGluRs in hippocampal LTP and hippocampus-dependent spatial learning.

Authors:  D Balschun; D Manahan-Vaughan; T Wagner; T Behnisch; K G Reymann; W Wetzel
Journal:  Learn Mem       Date:  1999 Mar-Apr       Impact factor: 2.460

Review 6.  Serotonin, memory, and the aging brain.

Authors:  W J McEntee; T H Crook
Journal:  Psychopharmacology (Berl)       Date:  1991       Impact factor: 4.530

7.  Effects of oxotremorine on inhibitory avoidance behaviour in two inbred strains of mice: interaction with 5-methoxy-NN-dimethyltriptamine.

Authors:  F Pavone; S Fagioli; C Castellano
Journal:  Psychopharmacology (Berl)       Date:  1993       Impact factor: 4.530

8.  Similar ameliorating effects of benzomorphans and 5-HT2 antagonists on drug-induced impairment of passive avoidance response in mice: comparison with acetylcholinesterase inhibitors.

Authors:  K Matsuno; T Senda; K Matsunaga; S Mita; H Kaneto
Journal:  Psychopharmacology (Berl)       Date:  1993       Impact factor: 4.530

9.  8-Hydroxy-2-(di-n-propylamino)tetralin impairs spatial learning in a water maze: role of postsynaptic 5-HT1A receptors.

Authors:  M Carli; R Samanin
Journal:  Br J Pharmacol       Date:  1992-03       Impact factor: 8.739

Review 10.  [Relations between specific neurochemical systems and memory: problems posed by dementia of the Alzheimer type].

Authors:  I Lussier; E Stip
Journal:  J Psychiatry Neurosci       Date:  1995-01       Impact factor: 6.186
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.