Literature DB >> 410449

Evidence for participation of cytochrome b5 in microsomal delta-6 desaturation of fatty acids.

T C Lee, R C Baker, N Stephens, F Snyder.   

Abstract

The delta-6 desaturation of linoleic acid to gamma-linolenic acid and oleic acid to 6,9-octadecadienoic acid by rat liver microsomes was investigated. Using a specific antibody prepared against purified rat liver cytochrome b5, we demonstrated that cytochrome b5 participated in delta-6 desaturation of both fatty acids. The reaction products were identified as their methyl ester derivatives by argentation thin-layer chromatography, gas-liquid chromatography, and reductive ozonolysis followed by gas-liquid chromatography.

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Year:  1977        PMID： 410449     DOI： 10.1016/0005-2760(77)90228-4

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN： 0006-3002


  9 in total

1.  Primary Structure of Cytochrome b(5) from Cauliflower (Brassica oleracea L.) Deduced from Peptide and cDNA Sequences.

Authors:  E V Kearns; P Keck; C R Somerville
Journal:  Plant Physiol       Date:  1992-07       Impact factor: 8.340

2.  Effect of ethanol administration on fatty acid desaturation.

Authors:  A M Nervi; R O Peluffo; R R Brenner; A I Leikin
Journal:  Lipids       Date:  1980-04       Impact factor: 1.880

3.  Liver microsomal delta 6 and delta 5 linoleic acid desaturation in female BB rats.

Authors:  B Chanussot; M Narce; J P Poisson
Journal:  Diabetologia       Date:  1989-11       Impact factor: 10.122

4.  Bilayer structure and physical dynamics of the cytochrome b5 dimyristoylphosphatidylcholine interaction.

Authors:  D W Chester; V Skita; H S Young; T Mavromoustakos; P Strittmatter
Journal:  Biophys J       Date:  1992-05       Impact factor: 4.033

5.  Hepatic Δ(9) and Δ(6) desaturase activities during the recovery period following carbon tetrachloride poisoningdesaturase activities during the recovery period following carbon tetrachloride poisoning.

Authors:  J P Carreau; D Frommel; T T Nguyen; P Mazliak
Journal:  Lipids       Date:  1980-09       Impact factor: 1.880

6.  Lipids of liver, kidney, spleen and muscle in a case of generalized deficiency of cytochrome b5 reductase in congenital methemoglobinemia with mental retardation.

Authors:  H Hirono
Journal:  Lipids       Date:  1984-01       Impact factor: 1.880

7.  Tobacco cytochrome b5: cDNA isolation, expression analysis and in vitro protein targeting.

Authors:  M A Smith; A K Stobart; P R Shewry; J A Napier
Journal:  Plant Mol Biol       Date:  1994-06       Impact factor: 4.076

8.  Expression of a biologically active plant cytochrome b5 in Escherichia coli.

Authors:  M A Smith; J A Napier; S Stymne; A S Tatham; P R Shewry; A K Stobart
Journal:  Biochem J       Date:  1994-10-01       Impact factor: 3.857

9.  Isolation of a cDNA encoding a cytochrome b5 specifically expressed in developing tobacco seeds.

Authors:  J A Napier; M A Smith; A K Stobart; P R Shewry
Journal:  Planta       Date:  1995       Impact factor: 4.116
  9 in total

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