| Literature DB >> 7371698 |
J L Brazier, J Descotes, N Lery, M Ollagnier, J C Evreux.
Abstract
The pharmacokinetics of caffeine are greatly altered by concomitant administration of idrocilamide. In four healthy volunteers id rocilamide inhibited the biotransformation of caffeine and increased its half-life nine times. The untoward neuropsychiatric effects of idrocilamide are the consequence of abnormal accumulation of caffeine in regular consumers of caffeine-containing foods and beverages.Entities:
Mesh:
Substances:
Year: 1980 PMID: 7371698 DOI: 10.1007/bf00561675
Source DB: PubMed Journal: Eur J Clin Pharmacol ISSN: 0031-6970 Impact factor: 2.953