Literature DB >> 7370374

The crossover experiment for clinical trials.

B W Brown.   

Abstract

The two-period crossover or changeover design for clinical trials is compared with other simple designs in terms of statistical precision and cost. The sensitivity of the crossover to bias due to carryover effects is examined. The feasibility of using the crossover data to test for the existence of carryover effects is investigated and found to be uneconomical. A numerical example is presented.

Mesh：

Year:  1980        PMID： 7370374

Source DB:  PubMed          Journal:  Biometrics        ISSN： 0006-341X            Impact factor:   2.571


  29 in total

1.  Tracing method in the assessment of retinal capillary blood flow velocity by fluorescein angiography with scanning laser ophthalmoscope.

Authors:  Hideharu Funatsu; Kumi Sakata; Seiyo Harino; Yukio Okuzawa; Hidetaka Noma; Sadao Hori
Journal:  Jpn J Ophthalmol       Date:  2006 Jan-Feb       Impact factor: 2.447

2.  Cost-efficient higher-order crossover designs in comparative bioavailability studies.

Authors:  Jihao Zhou; Ying Yuan; Rebecca Reynolds; Susan Raber; Youjuan Li
Journal:  Clin Pharmacokinet       Date:  2006       Impact factor: 6.447

3.  Efficacy of alternate day versus daily dosing of rosuvastatin.

Authors:  Daisy Dulay; Stephen A LaHaye; Karen A Lahey; Andrew G Day
Journal:  Can J Cardiol       Date:  2009-02       Impact factor: 5.223

4.  A randomized controlled trial of a computer-based physician workstation in an outpatient setting: implementation barriers to outcome evaluation.

Authors:  B L Rotman; A N Sullivan; T W McDonald; B W Brown; P DeSmedt; D Goodnature; M C Higgins; H J Suermondt; C Young; D K Owens
Journal:  J Am Med Inform Assoc       Date:  1996 Sep-Oct       Impact factor: 4.497

5.  The search for more clinically meaningful research designs: single-patient randomized clinical trials.

Authors:  M S Porta
Journal:  J Gen Intern Med       Date:  1986 Nov-Dec       Impact factor: 5.128

6.  Cross-over comparison of the fixed combination of hydrochlorothiazide and triamterene and the free combination of furosemide and triamterene in the maintenance treatment of congestive heart failure.

Authors:  A J Funke Küpper; H Fintelman; M C Huige; J J Koolen; K L Liem; F A Lustermans
Journal:  Eur J Clin Pharmacol       Date:  1986       Impact factor: 2.953

7.  Assessment of antitussive efficacy of dextromethorphan in smoking related cough: objective vs. subjective measures.

Authors:  James Ramsay; Caroline Wright; Rachel Thompson; David Hull; Alyn H Morice
Journal:  Br J Clin Pharmacol       Date:  2008-02-15       Impact factor: 4.335

8.  Treatment Heterogeneity and Individual Qualitative Interaction.

Authors:  Robert S Poulson; Gary L Gadbury; David B Allison
Journal:  Am Stat       Date:  2012-06-12       Impact factor: 8.710

Review 9.  Design, analysis, and presentation of crossover trials.

Authors:  Edward J Mills; An-Wen Chan; Ping Wu; Andy Vail; Gordon H Guyatt; Douglas G Altman
Journal:  Trials       Date:  2009-04-30       Impact factor: 2.279

10.  Comparison of the efficacy of administering a combination of ezetimibe plus fenofibrate versus atorvastatin monotherapy in the treatment of dyslipidemia.

Authors:  Shoba Sujana Kumar; Karen A Lahey; Andrew Day; Stephen A LaHaye
Journal:  Lipids Health Dis       Date:  2009-12-17       Impact factor: 3.876
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.