Literature DB >> 7370000

Inhibition of urea-cycle activity by high concentrations of alanine.

H E Hensgens, A J Meijer.   

Abstract

1. Conditions are described in which high intracellular alanine concentrations inhibit urea-cycle flux in isolated hepatocytes. 2. Inhibition of urea-cycle flux by added alanine is DL-cycloserine-insensitive and is accompanied by an increase in intracellular citrulline and a decrease in ornithine. 3. Argininosuccinate synthetase (EC 6.3.4.5) activity in rat liver cytosol is inhibited by alanine in a competitive manner with respect to citrulline. It is concluded that this effects is the primary cause of inhibition of urea-cycle flux by alanine.

Entities:  

Mesh：

Substances：

Year:  1980        PMID： 7370000      PMCID： PMC1161497          DOI： 10.1042/bj1860001

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  14 in total

1.  The enzymic hydrolysis of adenosine triphosphate by liver mitochondria. I. Activities at different pH values.

Authors:  D K MYERS; E C SLATER
Journal:  Biochem J       Date:  1957-12       Impact factor: 3.857

2.  Some regulatory mechanisms in the synthesis of urea in the mammalian liver.

Authors:  H A Krebs; R Hems; P Lund
Journal:  Adv Enzyme Regul       Date:  1973

3.  The distribution of hepatic metabolites and the control of the pathways of carbohydrate metabolism in animals of different dietary and hormonal status.

Authors:  A L Greenbaum; K A Gumaa; P McLean
Journal:  Arch Biochem Biophys       Date:  1971-04       Impact factor: 4.013

4.  Purification and properties of arginase of rat kidney.

Authors:  G A Kaysen; H J Strecker
Journal:  Biochem J       Date:  1973-08       Impact factor: 3.857

5.  The interrelationship between ureogenesis and protein synthesis in isolated rat-liver cells.

Authors:  H E Hensgens; A J Meijer
Journal:  Biochim Biophys Acta       Date:  1979-02-01

6.  Ornithine transcarbamylase from Streptococcus faecalis and bovine liver. II. Multiple binding sites for carbamyl-P and L-norvaline, correlation with steady state kinetics.

Authors:  M Marshall; P P Cohen
Journal:  J Biol Chem       Date:  1972-03-25       Impact factor: 5.157

7.  Role of anion translocation across the mitochondrial membrane in the regulation of urea synthesis from ammonia by isolated rat hepatocytes.

Authors:  A J Meijer; J A Gimpel; G A Deleeuw; J M Tager; J R Williamson
Journal:  J Biol Chem       Date:  1975-10-10       Impact factor: 5.157

8.  Mechanisms for the formation of alanine and aspartate on rat liver in vivo after administration of ammonium chloride.

Authors:  J T Brosnan; D H Williamson
Journal:  Biochem J       Date:  1974-03       Impact factor: 3.857

9.  Effects of ischaemia on metabolite concentrations in rat liver.

Authors:  J T Brosnan; H A Krebs; D H Williamson
Journal:  Biochem J       Date:  1970-03       Impact factor: 3.857

10.  Interrelations between ureogenesis and gluconeogenesis in isolated hepatocytes. The role of antion transport and the competition for energy.

Authors:  A B Wojtczak; E I Wałajtys-Rode; M J Geelen
Journal:  Biochem J       Date:  1978-02-15       Impact factor: 3.857
View more
  4 in total

1.  Shifts in the carbohydrate, polyol, and amino acid pools during rapid cold-hardening and diapause-associated cold-hardening in flesh flies (Sarcophaga crassipalpis): a metabolomic comparison.

Authors:  M Robert Michaud; David L Denlinger
Journal:  J Comp Physiol B       Date:  2007-06-19       Impact factor: 2.200

2.  Exogenous hyperglucagonaemia in insulin controlled diabetic rats increases urea excretion and nitrogen loss from organs.

Authors:  T P Almdal; H Vilstrup
Journal:  Diabetologia       Date:  1988-11       Impact factor: 10.122

3.  Mitochondrial and cytosolic ATP/ADP ratios in isolated hepatocytes. A comparison of the digitonin method and the non-aqueous fractionation procedure.

Authors:  S Soboll; T P Akerboom; W D Schwenke; R Haase; H Sies
Journal:  Biochem J       Date:  1980-12-15       Impact factor: 3.857

4.  Control of alanine metabolism in rat liver by transport processes or cellular metabolism.

Authors:  P Fafournoux; C Rémésy; C Demigné
Journal:  Biochem J       Date:  1983-03-15       Impact factor: 3.857
  4 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.