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Literature DB >> 736792

Neurotoxicity of organophosphorus pesticides: predictions can be based on in vitro studies with hen and human enzymes.

Abstract

The comparative inhibitory power of organophosphorus esters in vitro against hen brain acetylcholinesterase and neurotoxic esterase correlates with their comparative effects (death or delayed neuropathy) in vivo. Further comparisons of the in vitro effects seen with hen and human enzymes facilitates extrapolations to the human in vivo situation.

Entities: Chemical Disease Species

Mesh：

Substances：

Year: 1978 PMID： 736792 DOI： 10.1007/bf00354093

Source DB: PubMed Journal: Arch Toxicol ISSN： 0340-5761 Impact factor: 5.153

15 in total

Review 1. The delayed neuropathy caused by some organophosphorus esters: mechanism and challenge.

Authors: M K Johnson
Journal: CRC Crit Rev Toxicol Date: 1975-06

2. Paralytic and related effects of certain organic phosphorus compounds.

Authors: W F DURHAM; T B GAINES; W J HAYES
Journal: AMA Arch Ind Health Date: 1956-04

3. Paralysis following poisoning by a new organic phosphorus insecticide (mipafox); report on two cases.

Authors: P L BIDSTRUP; J A BONNELL; A G BECKETT
Journal: Br Med J Date: 1953-05-16

4. Core/targetoid fibres and multiple cytoplasmic bodies in organophosphate neuropathy.

Authors: N Fukuhara; M Hoshi; S Mori
Journal: Acta Neuropathol Date: 1977-10-10 Impact factor: 17.088

5. The primary biochemical lesion leading to the delayed neurotoxic effects of some organophosphorus esters.

Authors: M K Johnson
Journal: J Neurochem Date: 1974-10 Impact factor: 5.372

6. The acute toxicity of dichloroalkyl aryl phosphates in relation to chemical structure.

Authors: W R Pickering; J C Malone
Journal: Biochem Pharmacol Date: 1967-07-07 Impact factor: 5.858

Review 7. Organophosphorus esters causing delayed neurotoxic effects: mechanism of action and structure activity studies.

Authors: M K Johnson
Journal: Arch Toxicol Date: 1975-12-18 Impact factor: 5.153

8. Improved assay of neurotoxic esterase for screening organophosphates for delayed neurotoxicity potential.

Authors: M K Johnson
Journal: Arch Toxicol Date: 1977-06-18 Impact factor: 5.153

9. The anomalous behaviour of dimethyl phosphates in the biochemical test for delayed neurotoxicity.

Authors: M K Johnson
Journal: Arch Toxicol Date: 1978-10-13 Impact factor: 5.153

10. The delayed neurotoxic effect of some organophosphorus compounds. Identification of the phosphorylation site as an esterase.

Authors: M K Johnson
Journal: Biochem J Date: 1969-10 Impact factor: 3.857

27 in total

1. Assessment of the neurotoxic potential of some methyl- and phenylphosphonates using a stable preparation of neuropathy target esterase from chicken brain.

Authors: G F Makhaeva; V V Malygin; I V Martynov
Journal: Dokl Biochem Biophys Date: 2001 Mar-Apr Impact factor: 0.788

2. Esterase profile and analysis of structure-inhibitor selectivity relationships for homologous phosphorylated 1-hydroperfluoroisopropanols.

Authors: G F Makhaeva; O G Serebryakova; N P Boltneva; T G Galenko; A Yu Aksinenko; V B Sokolov; I V Martynov
Journal: Dokl Biochem Biophys Date: 2008 Nov-Dec Impact factor: 0.788

3. Constructs of human neuropathy target esterase catalytic domain containing mutations related to motor neuron disease have altered enzymatic properties.

Authors: Nichole D Hein; Jeanne A Stuckey; Shirley R Rainier; John K Fink; Rudy J Richardson
Journal: Toxicol Lett Date: 2010-04-09 Impact factor: 4.372

Neurotoxicity of organophosphorus pesticides: predictions can be based on in vitro studies with hen and human enzymes.

Review 1. The delayed neuropathy caused by some organophosphorus esters: mechanism and challenge.

2. Paralytic and related effects of certain organic phosphorus compounds.

3. Paralysis following poisoning by a new organic phosphorus insecticide (mipafox); report on two cases.

4. Core/targetoid fibres and multiple cytoplasmic bodies in organophosphate neuropathy.

5. The primary biochemical lesion leading to the delayed neurotoxic effects of some organophosphorus esters.

6. The acute toxicity of dichloroalkyl aryl phosphates in relation to chemical structure.

Review 7. Organophosphorus esters causing delayed neurotoxic effects: mechanism of action and structure activity studies.

8. Improved assay of neurotoxic esterase for screening organophosphates for delayed neurotoxicity potential.

9. The anomalous behaviour of dimethyl phosphates in the biochemical test for delayed neurotoxicity.

10. The delayed neurotoxic effect of some organophosphorus compounds. Identification of the phosphorylation site as an esterase.

1. Assessment of the neurotoxic potential of some methyl- and phenylphosphonates using a stable preparation of neuropathy target esterase from chicken brain.

2. Esterase profile and analysis of structure-inhibitor selectivity relationships for homologous phosphorylated 1-hydroperfluoroisopropanols.

3. Constructs of human neuropathy target esterase catalytic domain containing mutations related to motor neuron disease have altered enzymatic properties.

4. Poisoning by organophosphorus insecticides and sensory neuropathy.

5. A benefit from mechanistic research in toxicology.

6. Delayed neuropathy by the organophosphorus nerve agents soman and tabun.

7. Interaction of methamidophos with hen and human acetylcholinesterase and neuropathy target esterase.

8. Occupational peripheral neuropathies.

9. Repeated small doses of a neurotoxic organophosphate. Monitoring of neurotoxic esterase in brain and spinal cord.

10. Neurotoxic esterase. Identification of two isoenzymes in hen brain.