| Literature DB >> 7363329 |
A K Hopper, L D Schultz, R A Shapiro.
Abstract
By using conditional loss of suppression an an assay, we have been successful in screening for a yeast mutant which is defective in tRNA processing. The los1-1 mutation causes an accumulation of a subset of precursor tRNAs at the nonpermissive temperature. These pre-tRNAs are like those which accumulate in the yeast mutant ts 136 (rna1) in that they have transcribed intervening sequences. The mutations at los1-1 and rna1 complement and segregate independently of each other. The los1-1 mutation affects the expression of all 8 tyrosine-inserting suppressor loci, but does not seem to affect rRNA or mRNA synthesis.Entities:
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Year: 1980 PMID： 7363329 DOI： 10.1016/s0092-8674(80)80050-x
Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582