Literature DB >> 7362683

Vertebral osteophyte formation in experimental disc degeneration. Morphologic and proteoglycan changes over time.

S J Lipson, H Muir.   

Abstract

Experimental intervertebral disc degeneration produced in rabbits by ventral nuclear herniation reliably produces vertebral osteophytes. Osteophytes arise from proliferating inner annular fibers which undergo metaplasia into cartilage, calcify, and proceed through an endochondral ossification sequence. Proteoglycans extracted from the osteophytes reveal that the degree of aggregation, molecular size of the monomer, and the chondroitin sulfate/keratin sulfate ratio are directly related to the cartilage state of the tissue.

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Year:  1980        PMID： 7362683     DOI： 10.1002/art.1780230309

Source DB:  PubMed          Journal:  Arthritis Rheum        ISSN： 0004-3591


  17 in total

Review 1.  Ageing and degenerative changes of the intervertebral disc and their impact on spinal flexibility.

Authors:  Fabio Galbusera; Marc van Rijsbergen; Keita Ito; Jacques M Huyghe; Marco Brayda-Bruno; Hans-Joachim Wilke
Journal:  Eur Spine J       Date:  2014-01-31       Impact factor: 3.134

2.  Quantitative measurement of disc space area before and after chemonucleolysis and nucleotomy.

Authors:  W Gördes; G Feuchtgruber; W Fritz
Journal:  Int Orthop       Date:  1989       Impact factor: 3.075

3.  A longitudinal study on an autoimmune murine model of ankylosing spondylitis.

Authors:  T Bárdos; Z Szabó; M Czipri; C Vermes; M Tunyogi-Csapó; R M Urban; K Mikecz; T T Glant
Journal:  Ann Rheum Dis       Date:  2005-01-07       Impact factor: 19.103

Review 4.  Proper animal experimental designs for preclinical research of biomaterials for intervertebral disc regeneration.

Authors:  Yizhong Peng; Xiangcheng Qing; Hongyang Shu; Shuo Tian; Wenbo Yang; Songfeng Chen; Hui Lin; Xiao Lv; Lei Zhao; Xi Chen; Feifei Pu; Donghua Huang; Xu Cao; Zengwu Shao
Journal:  Biomater Transl       Date:  2021-06-28

5.  Intervertebral disc degeneration: an experimental and numerical study using a rabbit model.

Authors:  Andrea Calvo-Echenique; José Cegoñino; Laura Correa-Martín; Luciano Bances; Amaya Pérez-Del Palomar
Journal:  Med Biol Eng Comput       Date:  2017-10-23       Impact factor: 2.602

6.  A longitudinal study of back pain and radiological changes in the lumbar spines of middle aged women. II. Radiographic findings.

Authors:  D P Symmons; A M van Hemert; J P Vandenbroucke; H A Valkenburg
Journal:  Ann Rheum Dis       Date:  1991-03       Impact factor: 19.103

Review 7.  Are animal models useful for studying human disc disorders/degeneration?

Authors:  Mauro Alini; Stephen M Eisenstein; Keita Ito; Christopher Little; A Annette Kettler; Koichi Masuda; James Melrose; Jim Ralphs; Ian Stokes; Hans Joachim Wilke
Journal:  Eur Spine J       Date:  2007-07-14       Impact factor: 3.134

8.  Puncture of a disc and application of nucleus pulposus induces disc herniation-like changes and osteophytes. An experimental study in rats.

Authors:  Kjell Olmarker
Journal:  Open Orthop J       Date:  2011-04-28

9.  BALB/c mice genetically susceptible to proteoglycan-induced arthritis and spondylitis show colony-dependent differences in disease penetrance.

Authors:  Balint Farkas; Ferenc Boldizsar; Oktavia Tarjanyi; Anna Laszlo; Simon M Lin; Gabor Hutas; Beata Tryniszewska; Aaron Mangold; Gyorgy Nagyeri; Holly L Rosenzweig; Alison Finnegan; Katalin Mikecz; Tibor T Glant
Journal:  Arthritis Res Ther       Date:  2009-02-16       Impact factor: 5.156

10.  A Novel Rat Tail Needle Minimally Invasive Puncture Model Using Three-Dimensional Printing for Disk Degeneration and Progressive Osteogenesis Research.

Authors:  Dongdong Xia; Meijun Yan; Xin Yin; Wenhao Hu; Chi Zhang; Baiwen Hu; Ting Ge; Xiaochuan Wu; Jin Xiao; Liang Gao; Junqi Liu; Jun Tan
Journal:  Front Cell Dev Biol       Date:  2021-06-03
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