Literature DB >> 7361100

Cytosolic and microsomal epoxide hydrolases: differential properties in mammalian liver.

K Ota, B D Hammock.   

Abstract

The epoxide hydrolase activities of the 100,000 g pellet (microsomal) and 100,00 g soluble (cystosolic) fractions of mouse, rat, and guinea pig liver were measured with three closely related compounds used as substrates. Differences between the species in the distribution of the cytosolic and microsomal hydrolases and in their substrate specificities and pH optima demonstrate why epoxide hydrolase activity in the cytosolic fraction was not detected earlier in spie of intensive work on the microsomal epoxide hydrolase.

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Year:  1980        PMID： 7361100     DOI： 10.1126/science.7361100

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  20 in total

1.  Detoxification of environmental mutagens and carcinogens: structure, mechanism, and evolution of liver epoxide hydrolase.

Authors:  M A Argiriadi; C Morisseau; B D Hammock; D W Christianson
Journal:  Proc Natl Acad Sci U S A       Date:  1999-09-14       Impact factor: 11.205

2.  Fatty acid chemical mediator provides insights into the pathology and treatment of Parkinson's disease.

Authors:  Cesar V Borlongan
Journal:  Proc Natl Acad Sci U S A       Date:  2018-05-30       Impact factor: 11.205

3.  Cytosolic epoxide hydrolase in fetal and adult human liver.

Authors:  G M Pacifici; C Colizzi; L Giuliani; A Rane
Journal:  Arch Toxicol       Date:  1983-12       Impact factor: 5.153

4.  Metabolism of xenobiotic compounds by enzymes in cell extracts of the fungus Cunninghamella elegans.

Authors:  L P Wackett; D T Gibson
Journal:  Biochem J       Date:  1982-07-01       Impact factor: 3.857

5.  Metabolic activation of drugs in mutagenicity tests in vitro.

Authors:  M B Roberfroid
Journal:  Arch Toxicol       Date:  1980-11       Impact factor: 5.153

6.  Immuno-electron-microscopic studies on the subcellular distribution of rat liver epoxide hydrolase and the effect of phenobarbitone and 2-acetamidofluorene treatment.

Authors:  F Waechter; P Bentley; M Germann; F Oesch; W Stäubli
Journal:  Biochem J       Date:  1982-03-15       Impact factor: 3.857

Review 7.  The 2014 Bernard B. Brodie award lecture-epoxide hydrolases: drug metabolism to therapeutics for chronic pain.

Authors:  Sean D Kodani; Bruce D Hammock
Journal:  Drug Metab Dispos       Date:  2015-03-11       Impact factor: 3.922

8.  The N-terminal domain of mammalian soluble epoxide hydrolase is a phosphatase.

Authors:  Annette Cronin; Sherry Mowbray; Heike Dürk; Shirli Homburg; Ingrid Fleming; Beate Fisslthaler; Franz Oesch; Michael Arand
Journal:  Proc Natl Acad Sci U S A       Date:  2003-02-06       Impact factor: 11.205

9.  Cytosolic epoxide hydrolase in humans: development and tissue distribution.

Authors:  G M Pacifici; A Temellini; L Giuliani; A Rane; H Thomas; F Oesch
Journal:  Arch Toxicol       Date:  1988       Impact factor: 5.153

10.  Hydrolysis of cis- and trans-epoxyeicosatrienoic acids by rat red blood cells.

Authors:  Houli Jiang; Angela G Zhu; Magdalena Mamczur; Christophe Morisseau; Bruce D Hammock; John R Falck; John C McGiff
Journal:  J Pharmacol Exp Ther       Date:  2008-04-29       Impact factor: 4.030
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