Literature DB >> 7361097

Successful culture of rat embryos on human serum: use in the detection of teratogens.

C L Chatot, N W Klein, J Piatek, L J Pierro.   

Abstract

Growth of head-fold-stage rat embryos cultured with human serum for 48 hours was enhanced by supplementation with glucose. Embryo growth (protein and DNA contents) varied with the source of the serum. Serum from 16 of 19 untreated subjects produced normal embryos. Serum from five subjects undergoing cancer chemotherapy and six subjects receiving anticonvulsants was either lethal or teratogenic.

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Year:  1980        PMID： 7361097     DOI： 10.1126/science.7361097

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  10 in total

1.  A simple method of culture of 11.5-day-old rat embryos in DMEM/F12 and 20% fetal bovine serum.

Authors:  A Ornoy; S Yacobi; P Yaffee
Journal:  J Anat       Date:  2003-10       Impact factor: 2.610

2.  The effect of macromolecular rat serum fractions on conceptuses cultured in human serum: role of transferrin.

Authors:  A P Gulamhusein; M K Pratten; C A Williams; F Beck
Journal:  J Anat       Date:  1990-02       Impact factor: 2.610

3.  Postimplantation embryo culture for the assessment of the teratogenic potential and potency of compounds.

Authors:  L Cicurel; B P Schmid
Journal:  Experientia       Date:  1988-10-15

4.  Morphological, total nucleic acid and total protein analyses of rat embryos cultured in supplemented and unsupplemented human serum.

Authors:  D Lear; A Clarke; A P Gulamhusein; M Huxham; F Beck
Journal:  J Anat       Date:  1983-09       Impact factor: 2.610

5.  Abnormal development of cultured rat embryos in rat and human sera prepared after vitamin A ingestion.

Authors:  C E Steele; J D Plenefisch; N W Klein
Journal:  Experientia       Date:  1982-10-15

6.  Modification and standardization of the culture of early postimplantation embryos for toxicological studies.

Authors:  S Klug; C Lewandowski; D Neubert
Journal:  Arch Toxicol       Date:  1985-12       Impact factor: 5.153

7.  Mitotic response and sister chromatid exchanges in lymphocytes cultured in sera from different sources.

Authors:  A F McFee; M N Sherrill
Journal:  Experientia       Date:  1981-01-15

8.  Human serum as a culture medium for rat embryos.

Authors:  C E Steele
Journal:  Experientia       Date:  1985-12-15

9.  Mouse whole embryo culture: Evaluating the requirement for rat serum as culture medium.

Authors:  Lucy H Culshaw; Dawn Savery; Nicholas D E Greene; Andrew J Copp
Journal:  Birth Defects Res       Date:  2019-06-24       Impact factor: 2.344

Review 10.  Teratological research using in vitro systems. I. Mammalian whole embryo culture.

Authors:  T J Flynn
Journal:  Environ Health Perspect       Date:  1987-06       Impact factor: 9.031
  10 in total

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