Transient blood flow reduction induced by intra-arterial injection of degradable starch microspheres. Experiments on rats.

Starch microspheres, degradable by endogenous blood amylase were selectively injected into the femoral and superior mesenteric arteries, respectively, to obtain temporary local ischemia in foot and gut of the rat. The experimental models are described. Studies with tracer microspheres demonstrated, that the blood flow in the foot and the small intestine immediately declined to near zero, but latter resumed control levels.