Literature DB >> 7353567

Intravenous clonazepam in the treatment of status epilepticus in children.

P J Congdon, W I Forsythe.   

Abstract

Seventeen children (age range 2 weeks to 15 years) who developed status epilepticus were treated with intravenous clonazepam (Rivotril). Status was promptly stopped in each instance with between 0.25 to 0.75 mg clonazepam. In 6 children who had a further episode of status epilepticus, diazepam 0.25 to 0.75 mg/kg was given. A comparison of their relative efficacy showed that in each case clonazepam had a more prolonged action. No serious side effects occurred and it was felt that i.v. clonazepam, because of its more prolonged action, could be the drug of choice in controlling status epilepticus.

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Year:  1980        PMID: 7353567     DOI: 10.1111/j.1528-1157.1980.tb04049.x

Source DB:  PubMed          Journal:  Epilepsia        ISSN: 0013-9580            Impact factor:   5.864


  9 in total

1.  Respiratory and sedative effects of clobazam and clonazepam in volunteers.

Authors:  J D Wildin; B J Pleuvry; G E Mawer; T Onon; L Millington
Journal:  Br J Clin Pharmacol       Date:  1990-02       Impact factor: 4.335

2.  Practice variability and efficacy of clonazepam, lorazepam, and midazolam in status epilepticus: A multicenter comparison.

Authors:  Vincent Alvarez; Jong Woo Lee; Frank W Drislane; M Brandon Westover; Jan Novy; Barbara A Dworetzky; Andrea O Rossetti
Journal:  Epilepsia       Date:  2015-07-03       Impact factor: 5.864

3.  Clonazepam in neonatal seizures: dose regimens and therapeutic efficacy.

Authors:  M André; M J Boutroy; G Bianchetti; P Vert; P L Morselli
Journal:  Eur J Clin Pharmacol       Date:  1991       Impact factor: 2.953

Review 4.  Pharmacokinetic optimization of benzodiazepine therapy for acute seizures. Focus on delivery routes.

Authors:  E Rey; J M Tréluyer; G Pons
Journal:  Clin Pharmacokinet       Date:  1999-06       Impact factor: 6.447

5.  Non-convulsive status epilepticus resistant to benzodiazepines.

Authors:  J H Livingston; J K Brown
Journal:  Arch Dis Child       Date:  1987-01       Impact factor: 3.791

6.  Plasma concentrations of clonazepam after single rectal administration.

Authors:  G W Rylance; J Poulton; R C Cherry; R E Cullen
Journal:  Arch Dis Child       Date:  1986-02       Impact factor: 3.791

7.  Clonazepam pharmacokinetics and therapeutic efficacy in neonatal seizures.

Authors:  M André; M J Boutroy; C Dubruc; J P Thenot; G Bianchetti; L Sola; P Vert; P L Morselli
Journal:  Eur J Clin Pharmacol       Date:  1986       Impact factor: 2.953

Review 8.  Pharmacotherapy for Status Epilepticus.

Authors:  Eugen Trinka; Julia Höfler; Markus Leitinger; Francesco Brigo
Journal:  Drugs       Date:  2015-09       Impact factor: 9.546

Review 9.  Benzodiazepines in the Management of Seizures and Status Epilepticus: A Review of Routes of Delivery, Pharmacokinetics, Efficacy, and Tolerability.

Authors:  Adam Strzelczyk; Laurent M Willems; Ricardo Kienitz; Lara Kay; Isabelle Beuchat; Sarah Gelhard; Sophie von Brauchitsch; Catrin Mann; Alexandra Lucaciu; Jan-Hendrik Schäfer; Kai Siebenbrodt; Johann-Philipp Zöllner; Susanne Schubert-Bast; Felix Rosenow
Journal:  CNS Drugs       Date:  2022-08-16       Impact factor: 6.497

  9 in total

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