Literature DB >> 3954443

Plasma concentrations of clonazepam after single rectal administration.

G W Rylance, J Poulton, R C Cherry, R E Cullen.   

Abstract

Clonazepam was administered rectally to six children aged 1.4 to 4.7 years in a dose of 0.05 mg/kg and to five children aged 1.4 to 4.1 years in a dose of 0.1 mg/kg. Plasma concentrations indicate that it is rapidly absorbed, and it may therefore be an alternative to rectal administration of diazepam in continuing convulsions.

Entities:  

Mesh：

Substances：

Year:  1986        PMID： 3954443      PMCID： PMC1777570          DOI： 10.1136/adc.61.2.186

Source DB:  PubMed          Journal:  Arch Dis Child        ISSN： 0003-9888            Impact factor:   3.791


  13 in total

1.  Plasma levels of diazepam after parenteral and rectal administration in children.

Authors:  S Agurell; A Berlin; H Ferngren; B Hellström
Journal:  Epilepsia       Date:  1975-06       Impact factor: 5.864

2.  Plasma-diazepam in infants after rectal administration in solution and by suppository.

Authors:  F U Knudsen
Journal:  Acta Paediatr Scand       Date:  1977-09

3.  The use of clonazepam as an anticonvulsant--clinical evaluation.

Authors:  P F Bladin
Journal:  Med J Aust       Date:  1973-04-07       Impact factor: 7.738

4.  [A new possibility in the treatment of status epilepticus in childhood with i.v. valium].

Authors:  P Bamberger; A Matthes
Journal:  Z Kinderheilkd       Date:  1966-01-17

5.  Serum concentration of clonazepam after rectal administration.

Authors:  P Klosterskov Jensen; K Abild; M Nøhr Poulsen
Journal:  Acta Neurol Scand       Date:  1983-12       Impact factor: 3.209

6.  Determination of clonazepam and flunitrazepam in blood by electron-capture gas-liquid chromatography.

Authors:  J A de Silva; I Bekersky
Journal:  J Chromatogr       Date:  1974-11-06

7.  Serum clonazepam concentrations in children with absence seizures.

Authors:  F E Dreifuss; J K Penry; S W Rose; H J Kupferberg; P Dyken; S Sato
Journal:  Neurology       Date:  1975-03       Impact factor: 9.910

8.  Assay of underivatized intrazepam and clonazepam in plasma by capillary gas chromatography applied to pharmacokinetic and bioavailability studies in humans.

Authors:  A G de Boer; J Röst-Kaiser; H Bracht; D D Breimer
Journal:  J Chromatogr       Date:  1978-01-01

9.  Diazepam treatment for acute convulsions in children. A report of 41 patients, three with plasma levels.

Authors:  H G Ferngren
Journal:  Epilepsia       Date:  1974-03       Impact factor: 5.864

10.  Febrile convulsions--what do parents do?

Authors:  N Rutter; D H Metcalfe
Journal:  Br Med J       Date:  1978-11-11
View more
  7 in total

Review 1.  Pharmacokinetics of rectal drug administration, Part II. Clinical applications of peripherally acting drugs, and conclusions.

Authors:  E J van Hoogdalem; A G de Boer; D D Breimer
Journal:  Clin Pharmacokinet       Date:  1991-08       Impact factor: 6.447

Review 2.  Perioperative substitution of anti-epileptic drugs.

Authors:  Wilma S W Wichards; Alfred F A M Schobben; Frans S S Leijten
Journal:  J Neurol       Date:  2013-09-01       Impact factor: 4.849

3.  Absorption of clonazepam after intranasal and buccal administration.

Authors:  M W Schols-Hendriks; J J Lohman; R Janknegt; J J Korten; F W Merkus; P M Hooymans
Journal:  Br J Clin Pharmacol       Date:  1995-04       Impact factor: 4.335

Review 4.  Optimum management of febrile seizures in childhood.

Authors:  F U Knudsen
Journal:  Drugs       Date:  1988-07       Impact factor: 9.546

Review 5.  Pharmacokinetic optimization of benzodiazepine therapy for acute seizures. Focus on delivery routes.

Authors:  E Rey; J M Tréluyer; G Pons
Journal:  Clin Pharmacokinet       Date:  1999-06       Impact factor: 6.447

6.  Long term outcome of prophylaxis for febrile convulsions.

Authors:  F U Knudsen; A Paerregaard; R Andersen; J Andresen
Journal:  Arch Dis Child       Date:  1996-01       Impact factor: 3.791

Review 7.  Benzodiazepines in the Management of Seizures and Status Epilepticus: A Review of Routes of Delivery, Pharmacokinetics, Efficacy, and Tolerability.

Authors:  Adam Strzelczyk; Laurent M Willems; Ricardo Kienitz; Lara Kay; Isabelle Beuchat; Sarah Gelhard; Sophie von Brauchitsch; Catrin Mann; Alexandra Lucaciu; Jan-Hendrik Schäfer; Kai Siebenbrodt; Johann-Philipp Zöllner; Susanne Schubert-Bast; Felix Rosenow
Journal:  CNS Drugs       Date:  2022-08-16       Impact factor: 6.497
  7 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.