| Literature DB >> 7352894 |
K E Fox, R E Brummett, R Brown, D Himes.
Abstract
Dose-response experiments comparing the ototoxic liability of the aminoglycoside antibiotics gentamicin sulfate and gentamicin C1 sulfate were conducted on guinea pigs. Measures of cochlear electrophysiology, histology, and the pharmacokinetic disposition of the drugs in the plasma and perilymph were made. Electrophysiological and histological measures indicated that gentamicin is more ototoxic than is gentamicin C1.Entities:
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Year: 1980 PMID： 7352894 DOI： 10.1001/archotol.1980.00790250046009
Source DB: PubMed Journal: Arch Otolaryngol ISSN： 0003-9977