Literature DB >> 7350184

Evidence from radioligand assays that somatomedin-C and insulin-like growth factor-I are similar to each other and different from other somatomedins.

J J Van Wyk, M E Svoboda, L E Underwood.   

Abstract

Somatomedin-C (SM-C) and insulin-like growth factor I (IGF-I) produced identical curves of competition in a RIA for SM-C, and in placental cell membrane receptor assays for SM-C and insulin. Somatomedin-A (SM-A), insulin-like growth factor II (IGF-II) and two forms of multiplication stimulating activity (MSA) were less than 5% as potent as SM-C/IGF-I in the RIA and less than 50% that of SM-C/IGFi in the SM-C receptor assay. In the insulin receptor assay, IGF-II and MSA III-2 were much more potent than SM-C/IGF-I. The present data suggest that SM-C and IGF-I are functionally identical substances.

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Year:  1980        PMID： 7350184     DOI： 10.1210/jcem-50-1-206

Source DB:  PubMed          Journal:  J Clin Endocrinol Metab        ISSN： 0021-972X            Impact factor:   5.958


  18 in total

1.  Dietary components that regulate serum somatomedin-C concentrations in humans.

Authors:  W L Isley; L E Underwood; D R Clemmons
Journal:  J Clin Invest       Date:  1983-02       Impact factor: 14.808

2.  Effect of insulin-like growth factor on collagen and glycosaminoglycan synthesis by rabbit articular chondrocytes in culture.

Authors:  H L Guenther; H E Guenther; E R Froesch; H Fleisch
Journal:  Experientia       Date:  1982-08-15

3.  Total synthesis of insulin-like growth factor I (somatomedin C).

Authors:  C H Li; D Yamashiro; D Gospodarowicz; S L Kaplan; G Van Vliet
Journal:  Proc Natl Acad Sci U S A       Date:  1983-04       Impact factor: 11.205

4.  Effect of insulinlike growth factor I on DNA and protein synthesis in cultured rat calvaria.

Authors:  E Canalis
Journal:  J Clin Invest       Date:  1980-10       Impact factor: 14.808

5.  Alveolar macrophages release an insulin-like growth factor I-type molecule.

Authors:  W N Rom; P Basset; G A Fells; T Nukiwa; B C Trapnell; R G Crysal
Journal:  J Clin Invest       Date:  1988-11       Impact factor: 14.808

6.  Stimulation of proteoglycan biosynthesis by serum and insulin-like growth factor-I in cultured bovine articular cartilage.

Authors:  D J McQuillan; C J Handley; M A Campbell; S Bolis; V E Milway; A C Herington
Journal:  Biochem J       Date:  1986-12-01       Impact factor: 3.857

7.  Comparative binding of bovine, human and rat insulin-like growth factors to membrane receptors and to antibodies against human insulin-like growth factor-1.

Authors:  L C Read; F J Ballard; G L Francis; R C Baxter; C J Bagley; J C Wallace
Journal:  Biochem J       Date:  1986-01-01       Impact factor: 3.857

8.  Receptors for insulinlike growth factor I are defective in fibroblasts cultured from a patient with leprechaunism.

Authors:  E E Van Obberghen-Schilling; M M Rechler; J A Romanus; A B Knight; S P Nissley; R E Humbel
Journal:  J Clin Invest       Date:  1981-11       Impact factor: 14.808

9.  Antireceptor antibodies as probes of insulinlike growth factor receptor structure.

Authors:  M Kasuga; N Sasaki; C R Kahn; S P Nissley; M M Rechler
Journal:  J Clin Invest       Date:  1983-10       Impact factor: 14.808

10.  Human embryonic somatomedin.

Authors:  V R Sara; K Hall; C H Rodeck; L Wetterberg
Journal:  Proc Natl Acad Sci U S A       Date:  1981-05       Impact factor: 11.205
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