Literature DB >> 73466

Ly and Ia phenotype of suppressor T cells induced by graft-vs.-host reaction.

F L Shand.   

Abstract

Suppressor T cells were generated in (CBA X C57BL)F1 mice undergoing graft-vs.-host (GvH) reaction and treated with anti-Ly and anti-Ia antisera to determine their membrane antigen phenotype. Pretreatment of CBA-induced GvH suppressor T cells with anti-Ly-1.1, anti-Ly-2.1 or anti-Iak antisera plus complement abrogated their suppressive properties when tested against primed F1 spleen cells in vitro. In contrast, concanavalin A (Con A)-induced suppressor T cells were insensitive to anti-Ly-1.1 serum. It is concluded that GvH-induced suppressor T cells are Ly-1+,2+,3+,Ia+, and thus distinct from Con A or antigen-induced suppressor T cells.

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Year:  1977        PMID： 73466     DOI： 10.1002/eji.1830071019

Source DB:  PubMed          Journal:  Eur J Immunol        ISSN： 0014-2980            Impact factor:   5.532


  8 in total

1.  T-lymphocyte heterogeneity in the rat: separation of functional subpopulations using a monoclonal antibody.

Authors:  R A White; D W Mason; A F Williams; G Galfre; C Milstein
Journal:  J Exp Med       Date:  1978-09-01       Impact factor: 14.307

2.  Rabbit anti-EL4 serum. A reagent which discriminates between murine cytotoxic and suppressor cells.

Authors:  L Al-Sakkaf; A Cooke; L Heppel; P Hutchings; B Jones
Journal:  Immunology       Date:  1979-11       Impact factor: 7.397

3.  Characterization studies of suppressor cells in murine bone marrow chimaeras.

Authors:  M Imamura; H Fujimoto; T Fukuhara; M Kobayashi; M Kasai; K Sakurada; T Miyazaki
Journal:  Immunology       Date:  1987-01       Impact factor: 7.397

4.  B cell precursor growth-promoting activity. Purification and characterization of a growth factor active on lymphocyte precursors.

Authors:  A E Namen; A E Schmierer; C J March; R W Overell; L S Park; D L Urdal; D Y Mochizuki
Journal:  J Exp Med       Date:  1988-03-01       Impact factor: 14.307

5.  Allosuppressor- and allohelper-T cells in acute and chronic graft-vs.-host (GVH) disease. III. Different Lyt subsets of donor T cells induce different pathological syndromes.

Authors:  A G Rolink; E Gleichmann
Journal:  J Exp Med       Date:  1983-08-01       Impact factor: 14.307

6.  Allosuppressor and allohelper T cells in acute and chronic graft-vs.-host disease. II. F1 recipients carrying mutations at H-2K and/or I-A.

Authors:  A G Rolink; S T Pals; E Gleichmann
Journal:  J Exp Med       Date:  1983-02-01       Impact factor: 14.307

7.  Delayed-type hypersensitivity to influenza virus. Induction of antigen-specific suppressor T cells for delayed-type hypersensitivity to hemagglutinin during influenza virus infection in mice.

Authors:  F Y Liew; S M Russell
Journal:  J Exp Med       Date:  1980-04-01       Impact factor: 14.307

8.  Allosuppressor and allohelper T cells in acute and chronic graft-vs-host disease. V. F1 mice with secondary chronic GVHD contain F1-reactive allohelper but no allosuppressor T cells.

Authors:  S T Pals; H Gleichmann; E Gleichmann
Journal:  J Exp Med       Date:  1984-02-01       Impact factor: 14.307
  8 in total

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