Metabolic studies in vivo with arylamines.

Metabolic experiments have furnished leads on both the detoxification and activation pathways for aromatic amines. These consist largely of C- and N-hydroxylation, followed by conjugation with glucuronic or sulfuric acid, although other mechanisms may be involved. Current emphasis is on the N-hydroxylated derivatives as a precursor to the activated carcinogen. Metabolic patterns have furnished leads in some cases to account for the differences in susceptibility of various species to the carcinogenic aromatic amines, but discrepancies also occur.