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Literature DB >> 7340839

Mitochondrial and cytosolic ATP/ADP ratios in rat liver in vivo.

W D Schwenke, S Soboll, H J Seitz, H Sies.

Abstract

The ratio of ATP content/ADP content in livers from unanaesthetized fed rat was 0.9 in the mitochondrial matrix and 6.9 in the cytosol; the values for starved (48 h) animals were 1.0 and 5.9 respectively. The mitochondrial ratios observed in unanaesthetized animals were higher than in haemoglobin-free-perfused liver and lower than in isolated hepatocytes. Possible reasons for these differences may be related to oxygen supply and/or other factors. Further, data from anaesthetized rats with the liver exposed are given: mitochondrial ATP/ADP ratios were decreased with pentobarbital, but less so with ketamine as narcotic agent.

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Year: 1981 PMID： 7340839 PMCID： PMC1163549 DOI： 10.1042/bj2000405

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

14 in total

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2. Gradients of O2 concentration in hepatocytes.

Authors: D P Jones; H S Mason
Journal: J Biol Chem Date: 1978-07-25 Impact factor: 5.157

3. Coordinate control of intermediary metabolism in rat liver by the insulin/glucagon ratio during starvation and after glucose refeeding. Regulatory significance of long-chain acyl-CoA and cyclic AMP.

Authors: H J Seitz; M J Müller; W Krone; W Tarnowski
Journal: Arch Biochem Biophys Date: 1977-10 Impact factor: 4.013

4. Differences between the ATP-ADP ratios in the mitochondrial matrix and in the extramitochondrial space.

Authors: H W Heldt; M Klingenberg; M Milovancev
Journal: Eur J Biochem Date: 1972-11-07

5. The problem of tissue sampling from experimental animals with respect to freezing technique, anoxia, stress and narcosis. A new method for sampling rat liver tissue and the physiological values of glycolytic intermediates and related compounds.

Authors: R P Faupel; H J Seitz; W Tarnowski; V Thiemann; C Weiss
Journal: Arch Biochem Biophys Date: 1972-02 Impact factor: 4.013

6. Intramitochondrial and extramitochondrial concentrations of adenine nucleotides and inorganic phosphate in isolated hepatocytes from fasted rats.

Authors: T P Akerboom; H Bookelman; P F Zuurendonk; R van der Meer; J M Tager
Journal: Eur J Biochem Date: 1978-03-15

7. Measurement of the ATP/ADP ratio in mitochondria and in the extramitochondrial compartment by fractionation of freeze-stopped liver tissue in non-aqueous media.

Authors: R Elbers; H W Heldt; P Schmucker; S Soboll; H Wiese
Journal: Hoppe Seylers Z Physiol Chem Date: 1974-03

8. [Effect of the type of anesthesia on the levels of adenine nucleotides, lactate and pyruvate in the heart, liver and spleen of the rat].

Authors: H Reinauer; S Hollmann
Journal: Anaesthesist Date: 1966-10 Impact factor: 1.041

9. Subcellular metabolite concentrations. Dependence of mitochondrial and cytosolic ATP systems on the metabolic state of perfused rat liver.

Authors: S Soboll; R Scholz; H W Heldt
Journal: Eur J Biochem Date: 1978-06-15

10. Phosphorylation state of cytosolic and mitochondrial adenine nucleotides and of pyruvate dehydrogenase in isolated rat liver cells.

Authors: E A Siess; O H Wieland
Journal: Biochem J Date: 1976-04-15 Impact factor: 3.857

25 in total

1. Cyclophilin D and the mitochondrial permeability transition in kidney proximal tubules after hypoxic and ischemic injury.

Authors: Jeong Soon Park; Ratna Pasupulati; Thorsten Feldkamp; Nancy F Roeser; Joel M Weinberg
Journal: Am J Physiol Renal Physiol Date: 2011-04-13

Mitochondrial and cytosolic ATP/ADP ratios in rat liver in vivo.

1. [On the metabolite content and the metabolite concentration in the liver of the rat].

2. Gradients of O2 concentration in hepatocytes.

3. Coordinate control of intermediary metabolism in rat liver by the insulin/glucagon ratio during starvation and after glucose refeeding. Regulatory significance of long-chain acyl-CoA and cyclic AMP.

4. Differences between the ATP-ADP ratios in the mitochondrial matrix and in the extramitochondrial space.

5. The problem of tissue sampling from experimental animals with respect to freezing technique, anoxia, stress and narcosis. A new method for sampling rat liver tissue and the physiological values of glycolytic intermediates and related compounds.

6. Intramitochondrial and extramitochondrial concentrations of adenine nucleotides and inorganic phosphate in isolated hepatocytes from fasted rats.

7. Measurement of the ATP/ADP ratio in mitochondria and in the extramitochondrial compartment by fractionation of freeze-stopped liver tissue in non-aqueous media.

8. [Effect of the type of anesthesia on the levels of adenine nucleotides, lactate and pyruvate in the heart, liver and spleen of the rat].

9. Subcellular metabolite concentrations. Dependence of mitochondrial and cytosolic ATP systems on the metabolic state of perfused rat liver.

10. Phosphorylation state of cytosolic and mitochondrial adenine nucleotides and of pyruvate dehydrogenase in isolated rat liver cells.

1. Cyclophilin D and the mitochondrial permeability transition in kidney proximal tubules after hypoxic and ischemic injury.

2. Strategies for therapeutic hypometabothermia.

Review 3. Regulation of energy metabolism in liver.

Review 4. Assessing mitochondrial dysfunction in cells.

5. Imaging cytosolic NADH-NAD(+) redox state with a genetically encoded fluorescent biosensor.

Review 6. Regulation of cellular energy metabolism.

7. Effect of long-chain fatty acyl-CoA on mitochondrial and cytosolic ATP/ADP ratios in the intact liver cell.

8. Plasma membrane transport of thyroid hormone: its possible pathophysiological significance.

Review 9. VDAC Regulation: A Mitochondrial Target to Stop Cell Proliferation.

Review 10. Regulation of energy transduction and electron transfer in cytochrome c oxidase by adenine nucleotides.