Literature DB >> 7336718

The cellular basis of aging.

C H Scoggin.   

Abstract

Normal cells have only a finite life span before they die. The process known as aging may occur as a result of continued damage to the cell or as a result of expression of predetermined information within the genetic structure of the cell. Both processes lead to progressive cellular dysfunction which is evidenced by the organs of the body as aging. By understanding how individual cells age we will gain insight into how the body as a whole ages. The impact of such knowledge on science and society is a matter of both conjecture and concern.

Mesh:

Year:  1981        PMID: 7336718      PMCID: PMC1273329     

Source DB:  PubMed          Journal:  West J Med        ISSN: 0093-0415


  22 in total

1.  The maintenance of the accuracy of protein synthesis and its relevance to ageing.

Authors:  L E ORGEL
Journal:  Proc Natl Acad Sci U S A       Date:  1963-04       Impact factor: 11.205

2.  Aging: present status of our chemical knowledge.

Authors:  J BJORKSTEN
Journal:  J Am Geriatr Soc       Date:  1962-02       Impact factor: 5.562

3.  Alzheimer's disease, trisomy 21, and myeloproliferative disorders: associations suggesting a genetic diathesis.

Authors:  L L Heston
Journal:  Science       Date:  1977-04-15       Impact factor: 47.728

4.  Protein kinase activity associated with the avian sarcoma virus src gene product.

Authors:  M S Collett; R L Erikson
Journal:  Proc Natl Acad Sci U S A       Date:  1978-04       Impact factor: 11.205

Review 5.  The biology and pathology of oxygen radicals.

Authors:  J M McCord; I Fridovich
Journal:  Ann Intern Med       Date:  1978-07       Impact factor: 25.391

6.  Presenile dementia and Alzheimer's disease in mongolism.

Authors:  M I Olson; C M Shaw
Journal:  Brain       Date:  1969-03       Impact factor: 13.501

7.  Influence of the main histocompatibility complex on ageing in mice.

Authors:  G S Smith; R L Walford
Journal:  Nature       Date:  1977 Dec 22-29       Impact factor: 49.962

8.  The division cycle and RNA-synthesis in diploid human cells at different passage levels in vitro.

Authors:  A Macieira-Coelho; J Pontén; L Philipson
Journal:  Exp Cell Res       Date:  1966-06       Impact factor: 3.905

9.  Dimethyl sulfoxide prevents DNA nicking mediated by ionizing radiation or iron/hydrogen peroxide-generated hydroxyl radical.

Authors:  J E Repine; O W Pfenninger; D W Talmage; E M Berger; D E Pettijohn
Journal:  Proc Natl Acad Sci U S A       Date:  1981-02       Impact factor: 11.205

10.  Alterations in cyclic nucleotides and cyclase-specific activities in T lymphocytes of aging normal humans and patients with Down's syndrome.

Authors:  C F Tam; R L Walford
Journal:  J Immunol       Date:  1980-10       Impact factor: 5.422

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  2 in total

1.  Intravenous sedation in 200 geriatric patients undergoing office oral surgery.

Authors:  R L Campbell; P B Smith
Journal:  Anesth Prog       Date:  1997

2.  Vitamin E prevents oxidative modification of brain and lymphocyte band 3 proteins during aging.

Authors:  J E Poulin; C Cover; M R Gustafson; M B Kay
Journal:  Proc Natl Acad Sci U S A       Date:  1996-05-28       Impact factor: 11.205

  2 in total

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