Literature DB >> 17756099

Alzheimer's disease, trisomy 21, and myeloproliferative disorders: associations suggesting a genetic diathesis.

L L Heston.   

Abstract

Relatives of probands with Alzheimer's disease had excessive incidences of trisomy 21 and myeloproliferative disorders. Microtubules are structures that are likely to be affected by a genetic defect causing a predisposition to Alzheimer's disease, trisomy 21 and, possibly, to myeloproliferative disorders.

Entities:  

Year:  1977        PMID： 17756099     DOI： 10.1126/science.196.4287.322

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  12 in total

1.  Hypothesis: microtubules, a key to Alzheimer disease.

Authors:  S S Matsuyama; L F Jarvik
Journal:  Proc Natl Acad Sci U S A       Date:  1989-10       Impact factor: 11.205

2.  Alzheimer's disease.

Authors: 
Journal:  Br Med J       Date:  1980-11-22

3.  Pedigrees of 30 families with Alzheimer disease: associations with defective organization of microfilaments and microtubules.

Authors:  L L Heston; J White
Journal:  Behav Genet       Date:  1978-07       Impact factor: 2.805

4.  Charting the conquest of senility.

Authors:  R N Butler
Journal:  Bull N Y Acad Med       Date:  1982-05

5.  The cellular basis of aging.

Authors:  C H Scoggin
Journal:  West J Med       Date:  1981-12

6.  SV40 T-antigen expression in cultured fibroblasts from patients with Down syndrome and their parents.

Authors:  A S Lubiniecki; W A Blattner; G M Martin; P J Fialkow; H Dosik; C Eatherly; J F Fraumeni
Journal:  Am J Hum Genet       Date:  1979-07       Impact factor: 11.025

Review 7.  Cytogenetic abnormalities in cancer: with special emphasis on tumor heterogeneity.

Authors:  S Pathak
Journal:  Cancer Metastasis Rev       Date:  1990-02       Impact factor: 9.264

8.  Antiviral response of fibroblasts from familial Alzheimer's disease and Down's syndrome to human interferon-alpha.

Authors:  S L Mowshowitz; G J Dawson; T S Elizan
Journal:  J Neural Transm       Date:  1983       Impact factor: 3.575

9.  Linkage analysis of familial Alzheimer disease, using chromosome 21 markers.

Authors:  G D Schellenberg; M A Pericak-Vance; E M Wijsman; D K Moore; P C Gaskell; L A Yamaoka; J L Bebout; L Anderson; K A Welsh; C M Clark
Journal:  Am J Hum Genet       Date:  1991-03       Impact factor: 11.025

10.  Lymphocyte concanavalin A capping: a similarity between Down's syndrome and early onset primary degenerative dementia.

Authors:  M Duijndam-van den Berge; J G Goekoop
Journal:  J Neurol Neurosurg Psychiatry       Date:  1986-05       Impact factor: 10.154
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