Literature DB >> 7329654

A theory of the origin of life.

C B Olson.   

Abstract

Life on Earth is essentially nucleic acids (NAs) influencing peptide synthesis such that NA replication is favored. It is proposed that the ability to synthesize polypeptides evolved gradually - one peptide bond at a time. The proposed evolution of the peptide synthesis apparatus begins with a 'transfer NA' (tNA) which catalyzes the transfer of activated amino acids to accessible amino groups in its environment. The resulting 'capped molecules' (with single amino acid 'caps') in turn favor NA replication. The proposed evolution of the peptide synthesis apparatus from the tNA onward is characterized by a progressive increase in the number of amino acids per cap: two tNAs jointly produce a 'dipeptide cap', three tNAs jointly produce a 'tripeptide cap', etc. Messenger NAs evolve because they can specify the composition and sequence order of the peptide caps. Lastly, ribosomal NAs evolve. The origin, expansion, and standardization of the genetic code are discussed. It is proposed that the presence triplet code evolved by a process of codon length refinement, and the originally codons of varying lengths were allowable, as were unassigned bases between codons. An environmental supply of activated compounds for early evolving entities is proposed. An 'environmental retention and redistribution process' is proposed to have acted as a functional substitute for the cell wall and cell division of early evolving entities.

Entities:  

Mesh:

Substances:

Year:  1981        PMID: 7329654     DOI: 10.1007/bf00931490

Source DB:  PubMed          Journal:  Orig Life        ISSN: 0302-1688


  20 in total

1.  On the Evolution of Biochemical Syntheses.

Authors:  N H Horowitz
Journal:  Proc Natl Acad Sci U S A       Date:  1945-06       Impact factor: 11.205

2.  Evolution of the genetic apparatus.

Authors:  L E Orgel
Journal:  J Mol Biol       Date:  1968-12       Impact factor: 5.469

3.  Models for the evolution of codon assignments.

Authors:  C Woese
Journal:  J Mol Biol       Date:  1969-07-14       Impact factor: 5.469

4.  The molecular basis for the genetic code.

Authors:  C R Woese; D H Dugre; W C Saxinger; S A Dugre
Journal:  Proc Natl Acad Sci U S A       Date:  1966-04       Impact factor: 11.205

5.  On the evolution of the genetic code.

Authors:  C R Woese
Journal:  Proc Natl Acad Sci U S A       Date:  1965-12       Impact factor: 11.205

6.  Genetic code correlations: amino acids and their anticodon nucleotides.

Authors:  A L Weber; J C Lacey
Journal:  J Mol Evol       Date:  1978-08-02       Impact factor: 2.395

7.  Triplet nucleotide-amino-acid pairing; a stereochemical basis for the division between protein and non-protein amino-acids.

Authors:  P Dunnill
Journal:  Nature       Date:  1966-06-18       Impact factor: 49.962

8.  Studies on some interactions and reactions of oligonucleotides in aqueous solution.

Authors:  R Naylor; P T Gilham
Journal:  Biochemistry       Date:  1966-08       Impact factor: 3.162

9.  Studies of oligoadenylate formation on a poly (U) template.

Authors:  R Lohrmann; L E Orgel
Journal:  J Mol Evol       Date:  1979-03-15       Impact factor: 2.395

10.  Heteropolynucleotides as templates for non-enzymatic polymerizations.

Authors:  J Ninio; L E Orgel
Journal:  J Mol Evol       Date:  1978-12-29       Impact factor: 2.395

View more
  2 in total

1.  Theory of the origin, evolution, and nature of life.

Authors:  Erik D Andrulis
Journal:  Life (Basel)       Date:  2011-12-23

2.  Primeval procreative comet pond.

Authors:  B C Clark
Journal:  Orig Life Evol Biosph       Date:  1988       Impact factor: 1.950

  2 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.