Literature DB >> 7328593

Gastric antisecretory agents. 2. Antisecretory activity of 9-[(aminoalkyl)thio]-9H-xanthenes and 5-[(aminoalkyl)thio]-5H-[1]benzopyrano[2,3-b]pyridines.

J A Bristol, E H Gold, I Gross, R G Lovey, J F Long.   

Abstract

A series of 9-[(aminoalkyl)thio]-9H-xanthenes (3-6) and 5-[(aminoalkyl)thio]-5H-[1]benzopyrano[2,3-b]pyridines (7-10) possessing gastric antisecretory activity in the rat and dog is described Many of the compounds possessed good activity in the pylorus-ligated rat and several inhibited histamine-stimulated gastric acid secretion in the dog. The mechanism of acid secretion inhibition is not related to anticholinergic or histamine (H2) receptor antagonism.

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Year:  1981        PMID： 7328593     DOI： 10.1021/jm00140a020

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


  3 in total

1.  A facile tandem Michael addition/O-cyclization/elimination route to novel chromeno[3,2-c]pyridines.

Authors:  Remani Vasudevan Sumesh; Akilan Malathi; Raju Ranjith Kumar
Journal:  Mol Divers       Date:  2015-03-11       Impact factor: 2.943

2.  Convenient one-step synthesis of a medicinally relevant benzopyranopyridine system.

Authors:  Nikolai M Evdokimov; Artem S Kireev; Andrey A Yakovenko; Mikhail Yu Antipin; Igor V Magedov; Alexander Kornienko
Journal:  Tetrahedron Lett       Date:  2006-12-25       Impact factor: 2.415

3.  Catalyst-Solvent System for PASE Approach to Hydroxyquinolinone-Substituted Chromeno[2,3-b]pyridines Its Quantum Chemical Study and Investigation of Reaction Mechanism.

Authors:  Fedor V Ryzhkov; Yuliya E Ryzhkova; Michail N Elinson; Stepan V Vorobyev; Artem N Fakhrutdinov; Anatoly N Vereshchagin; Mikhail P Egorov
Journal:  Molecules       Date:  2020-05-31       Impact factor: 4.411
  3 in total

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