Literature DB >> 7326000

Impairment of effects of vasopressin on [1-14C]oleate metabolism in hepatocytes from obese (ob/ob) mice.

M W Edwards, M A Cawthorne, D H Williamson.   

Abstract

In hepatocytes from lean mice vasopressin decreased ketogenesis and increased 14CO2 production from [1-14C]oleate and glucose release; these effects were Ca2+-dependent. None of these effects of vasopressin were obtained with hepatocytes from obese (ob/ob) mice. Similarly, adrenaline did not increase 14CO2 production in these hepatocytes, but it stimulated glucose release. Possible reasons for the impairment of vasopressin action are discussed.

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Year:  1981        PMID： 7326000      PMCID： PMC1163235          DOI： 10.1042/bj1980239

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  18 in total

1.  Effect of food restriction on body composition of hereditary obese mice.

Authors:  L G ALONSO; T H MAREN
Journal:  Am J Physiol       Date:  1955-11

2.  Studies on the inhibition of hepatic lipogenesis by N-6,O-2'-dibutyryl adenosine 3',5'-monophosphate.

Authors:  R A Harris
Journal:  Arch Biochem Biophys       Date:  1975-07       Impact factor: 4.013

3.  Effects of lactation of ketogenesis from oleate or butyrate in rat hepatocytes.

Authors:  E Whitelaw; D H Williamson
Journal:  Biochem J       Date:  1977-06-15       Impact factor: 3.857

4.  Studies on the alpha-adrenergic activation of hepatic glucose output. I. Studies on the alpha-adrenergic activation of phosphorylase and gluconeogenesis and inactivation of glycogen synthase in isolated rat liver parenchymal cells.

Authors:  N J Hutson; F T Brumley; F D Assimacopoulos; S C Harper; J H Exton
Journal:  J Biol Chem       Date:  1976-09-10       Impact factor: 5.157

5.  Catabolic effects of adrenaline and angiotensin II in the perfused liver of normal and genetically obese (ob/ob) mice.

Authors:  G Y Ma; C D Gove; M A Cawthorne; D A Hems
Journal:  Clin Sci (Lond)       Date:  1979-05       Impact factor: 6.124

6.  Stimulation by vasopressin, angiotensin and oxytocin of gluconeogenesis in hepatocyte suspensions.

Authors:  P D Whitton; L M Rodrigues; D A Hems
Journal:  Biochem J       Date:  1978-12-15       Impact factor: 3.857

7.  Interactions between vasopressin and glucagon on ketogenesis and oleate metabolism in isolated hepatocytes from fed rats.

Authors:  D H Williamson; V Ilic; A F Tordoff; E V Ellington
Journal:  Biochem J       Date:  1980-02-15       Impact factor: 3.857

8.  Metabolic actions of vasopressin, glucagon and adrenalin in the intact rat.

Authors:  D A Hems; P D Whitton; G Y Ma
Journal:  Biochim Biophys Acta       Date:  1975-11-10

9.  The control by vasopressin of carbohydrate and lipid metabolism in the perfused rat liver.

Authors:  C J Kirk; D A Hems
Journal:  Biochim Biophys Acta       Date:  1979-04-03

10.  Development of obesity in diabetic mice pair-fed with lean siblings.

Authors:  J E Cox; T L Powley
Journal:  J Comp Physiol Psychol       Date:  1977-04
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  3 in total

1.  Effects of vasopressin and corticosterone on fatty acid metabolism and on the activities of glycerol phosphate acyltransferase and phosphatidate phosphohydrolase in rat hepatocytes.

Authors:  A D Pollard; D N Brindley
Journal:  Biochem J       Date:  1984-01-15       Impact factor: 3.857

2.  Mitochondrial Ca2+ transport in lean and genetically obese (ob/ob) mice.

Authors:  D R Fraser; P Trayhurn
Journal:  Biochem J       Date:  1983-07-15       Impact factor: 3.857

3.  Lack of vasopressin receptors in liver, but not in kidney, of ob/ob mice.

Authors:  F Assimacopoulos-Jeannet; B Cantau; G van de Werve; S Jard; B Jeanrenaud
Journal:  Biochem J       Date:  1983-11-15       Impact factor: 3.857
  3 in total

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