Literature DB >> 7325646

Effects of amphotericin B on hepatitis B virus.

H A Kessler, J Dixon, C R Howard, K Tsiquaye, A J Zuckerman.   

Abstract

We investigated the effects of amphotericin B (AmB) on the ultrastructure and biochemistry of hepatitis B virus (HBV) and hepatitis B surface antigen (HBsAg) particles. These effects were compared with those reported for AmB and other polyene antibiotics on other lipid-enveloped viruses and artificial membranes. Treatment of HBV particles with concentrations of AmB ranging from 5 to 250 microgram/ml resulted in (i) an increase in HBV deoxyribonucleic acid polymerase activity as the concentration of Amb increased; (ii) changes in the electron microscopic appearance of HBV ranging from increased penetration of negative stain into the lipid envelope to disruption of the virus; and (iii) an increase in density form 1.165 to 1.225 g/ml. In addition, AmB treatment of HBsAg particles resulted in disruption into a nonparticulate HBsAg-reactive fraction and an HBsAg-AmB complex fraction with no HBsAg immunoreactivity.

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Year:  1981        PMID： 7325646      PMCID： PMC181806          DOI： 10.1128/AAC.20.6.826

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  23 in total

Review 1.  Solubilization of membranes by detergents.

Authors:  A Helenius; K Simons
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Authors:  Y Nozawa; Y Kitajima; T Sekiya; Y Ito
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5.  Interaction of filipin 3 and amphotericin B with lecithin-sterol vesicles and cellular membranes. Spectral and electron microscope studies.

Authors:  R Bittman; W C Chen; O R Anderson
Journal:  Biochemistry       Date:  1974-03-26       Impact factor: 3.162

6.  Synergistic effect of amphotericin B and 1,3-bis(2-chloroethyl)-1-nitrosourea against a transplantable AKR leukemia.

Authors:  G Medoff; F Valeriote; R G Lynch; D Schlessinger; G S Kobayashi
Journal:  Cancer Res       Date:  1974-05       Impact factor: 12.701

7.  A pharmacologic guide to the clinical use of amphotericin B.

Authors:  D D Bindschadler; J E Bennett
Journal:  J Infect Dis       Date:  1969-10       Impact factor: 5.226

8.  Morphology of the isolated hemagglutinin and neuraminidase subunits of influenza virus.

Authors:  W G Laver; R C Valentine
Journal:  Virology       Date:  1969-05       Impact factor: 3.616

9.  Amphotericin B. New perspectives.

Authors:  C A Presant
Journal:  Arch Intern Med       Date:  1980-04

10.  Molecular basis for the selective toxicity of amphotericin B for yeast and filipin for animal cells.

Authors:  J Kotler-Brajtburg; H D Price; G Medoff; D Schlessinger; G S Kobayashi
Journal:  Antimicrob Agents Chemother       Date:  1974-04       Impact factor: 5.191
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  9 in total

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Review 4.  Sixty years of Amphotericin B: An Overview of the Main Antifungal Agent Used to Treat Invasive Fungal Infections.

Authors:  Francelise B Cavassin; João Luiz Baú-Carneiro; Rogério R Vilas-Boas; Flávio Queiroz-Telles
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5.  Antifungal Macrocycle Antibiotic Amphotericin B-Its Present and Future. Multidisciplinary Perspective for the Use in the Medical Practice.

Authors:  A A Baghirova; Kh M Kasumov
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Review 7.  Polyene Antibiotics Physical Chemistry and Their Effect on Lipid Membranes; Impacting Biological Processes and Medical Applications.

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8.  Amphotericin B Inhibits Enterovirus 71 Replication by Impeding Viral Entry.

Authors:  Fengwen Xu; Xiaoxiao Zhao; Siqi Hu; Jian Li; Lijuan Yin; Shan Mei; Tingting Liu; Ying Wang; Lili Ren; Shan Cen; Zhendong Zhao; Jianwei Wang; Qi Jin; Chen Liang; Bin Ai; Fei Guo
Journal:  Sci Rep       Date:  2016-09-09       Impact factor: 4.379

9.  Effect of deoxycholate, amphotericin B and fongizone on transmissible gastroenteritis coronavirus.

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  9 in total

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