Literature DB >> 7325160

Optimal sampling for pedigree analysis: relatives of affected probands.

E A Thompson.   

Abstract

Criteria and rules are derived for the most statistically efficient sampling of relatives of affected probands under a simple class of standard genetic models. Results show that the optimal relative type depends on the alternative hypotheses of particular interest. Thus, there is no uniformly optimal strategy, but the criteria can be used to derive the best strategy in any particular case; examples are given.

Mesh：

Year:  1981        PMID： 7325160      PMCID： PMC1685145     

Source DB:  PubMed          Journal:  Am J Hum Genet        ISSN： 0002-9297            Impact factor:   11.025


  9 in total

1.  Limits of the general two-allele single locus model with incomplete penetrance.

Authors:  B K Suarez; T Reich; J Trost
Journal:  Ann Hum Genet       Date:  1976-11       Impact factor: 1.670

2.  The estimation of pairwise relationships.

Authors:  E A Thompson
Journal:  Ann Hum Genet       Date:  1975-10       Impact factor: 1.670

3.  The inheritance of fingerprint patterns.

Authors:  H M Slatis; M B Katznelson; B Bonné-Tamir
Journal:  Am J Hum Genet       Date:  1976-05       Impact factor: 11.025

4.  Linkage analysis and the inheritance of arches in a Habbanite isolate.

Authors:  M W Anderson; B Bonné-Tamir; D Carmelli; E A Thompson
Journal:  Am J Hum Genet       Date:  1979-09       Impact factor: 11.025

5.  Sampling considerations in the gathering and analysis of pedigree data.

Authors:  R C Elston; E Sobel
Journal:  Am J Hum Genet       Date:  1979-01       Impact factor: 11.025

6.  Analysis of family resemblance. I. Introduction.

Authors:  N E Morton
Journal:  Am J Hum Genet       Date:  1974-05       Impact factor: 11.025

7.  Frequency in relatives for an all-or-none trait.

Authors:  J W James
Journal:  Ann Hum Genet       Date:  1971-07       Impact factor: 1.670

8.  Efficiency and robustness of pedigree segregation analysis.

Authors:  R C Go; R C Elston; E B Kaplan
Journal:  Am J Hum Genet       Date:  1978-01       Impact factor: 11.025

9.  Schizophrenia: the systematic construction of genetic models.

Authors:  J Stewart
Journal:  Am J Hum Genet       Date:  1980-01       Impact factor: 11.025
  9 in total
  3 in total

1.  Comparison of sequential and fixed-structure sampling of pedigrees in complex segregation analysis of a quantitative trait.

Authors:  M Boehnke; M R Young; P P Moll
Journal:  Am J Hum Genet       Date:  1988-09       Impact factor: 11.025

2.  Comparisons of different sampling designs for the determination of genetic transmission mechanisms in quantitative traits.

Authors:  T L Burns; P P Moll; M A Schork
Journal:  Am J Hum Genet       Date:  1984-09       Impact factor: 11.025

3.  An algorithm for optimal testing in co-segregation analysis.

Authors:  Ronald W Buie; John Michael O Rañola; Annie T Chen; Brian H Shirts
Journal:  Hum Mutat       Date:  2022-04-07       Impact factor: 4.878
  3 in total

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