Literature DB >> 7318992

Pseudocholinesterase in obesity: hypercaloric diet induced changes in experimental obese mice.

K M Kutty, S N Huang, K T Kean.   

Abstract

Pseudocholinesterase activity is significantly higher in liver and serum, but lower in adipose tissue of genetically obese, diabetic and gold thioglucose treated mice. Similar enzyme changes were also observed in lean mice on a high carbohydrate diet. A marked reduction (40%) in PChE activity occurred in the liver of genetically diabetic mice when starved for 24 h. These observations suggest that pseudocholinesterase induction in the liver and repression in the adipose tissue is affected by excessive caloric intake in obesity. This provides a model to study the biological function of PChE in health and disease.

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Year:  1981        PMID： 7318992     DOI： 10.1007/bf01989883

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  17 in total

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  8 in total

1.  Serum butyrylcholinesterase in type 2 diabetes mellitus: a biochemical and bioinformatics approach.

Authors:  G R Sridhar; G Nirmala; Allam Apparao; A S Madhavi; S Sreelatha; J Sudha Rani; P Vijayalakshmi
Journal:  Lipids Health Dis       Date:  2005-09-08       Impact factor: 3.876

2.  GWAS of butyrylcholinesterase activity identifies four novel loci, independent effects within BCHE and secondary associations with metabolic risk factors.

Authors:  Beben Benyamin; Rita P Middelberg; Penelope A Lind; Anne M Valle; Scott Gordon; Dale R Nyholt; Sarah E Medland; Anjali K Henders; Andrew C Heath; Pamela A F Madden; Peter M Visscher; Daniel T O'Connor; Grant W Montgomery; Nicholas G Martin; John B Whitfield
Journal:  Hum Mol Genet       Date:  2011-08-23       Impact factor: 6.150

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Authors:  V Annapurna; I Senciall; A J Davis; K M Kutty
Journal:  Diabetologia       Date:  1991-05       Impact factor: 10.122

4.  Changes of some serum parameters and amino acids content in rats after chronic sublethal doses of dimethoate.

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5.  Alzheimer's disease and type 2 diabetes mellitus: the cholinesterase connection?

Authors:  Gumpeny Ramachandra Sridhar; Hanuman Thota; Appa Rao Allam; Changalasetty Suresh Babu; Akula Siva Prasad; Ch Divakar
Journal:  Lipids Health Dis       Date:  2006-11-11       Impact factor: 3.876

6.  Association of Paraoxonase-1 Q192R (rs662) Single Nucleotide Variation with Cardiovascular Risk in Coffee Harvesters of Central Colombia.

Authors:  Fernando Siller-López; Sandra Garzón-Castaño; Martha E Ramos-Márquez; Iván Hernández-Cañaveral
Journal:  J Toxicol       Date:  2017-12-21

7.  Plasma cholinesterase is associated with Chinese adolescent overweight or obesity and metabolic syndrome prediction.

Authors:  Yanshuo Han; Yanan Ma; Yang Liu; Zhongyi Zhao; Shihan Zhen; Xuelian Yang; Zhiyong Xu; Deliang Wen
Journal:  Diabetes Metab Syndr Obes       Date:  2019-05-14       Impact factor: 3.168

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Authors:  Lidia Santarpia; Ilenia Grandone; Franco Contaldo; Fabrizio Pasanisi
Journal:  J Cachexia Sarcopenia Muscle       Date:  2012-09-06       Impact factor: 12.910
  8 in total

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