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Literature DB >> 731791

Genetic analysis of adenovirus type 2. VIII. Physical locations of temperature-sensitive mutations.

Abstract

Temperature-sensitive mutations of human adenoviruses can be physically located on the viral genome by determining the DNA structures of recombinants formed in genetic crosses between different members of the same subgroup. We have analyzed the DNA structures of many interserotypic recombinants formed in crosses between temperature-sensitive (ts) mutants of adenovirus type 2 and adenovirus type 5 with the restriction endonucleases BamHI, EcoRI, HindIII, and and Sma I. In this way, we have mapped the physical coordinates of adenovirus type 2 (Ad2) ts1, Ad2 ts3, Ad2 ts4, and Ad2 ts48, and refined the mapping of Ad5 ts1.

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Year: 1978 PMID： 731791 PMCID： PMC525790

Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103

34 in total

9. Physical mapping of adenovirus type 2 temperature-sensitive mutations by restriction endonuclease analysis of interserotypic recombinants.

Authors: J C D'Halluin; C Cousin; P Boulanger
Journal: J Virol Date: 1982-02 Impact factor: 5.103

10. Physical mapping of a large-plaque mutation of adenovirus type 2.

Authors: G Chinnadurai; S Chinnadurai; J Brusca
Journal: J Virol Date: 1979-11 Impact factor: 5.103

Genetic analysis of adenovirus type 2. VIII. Physical locations of temperature-sensitive mutations.

1. Physical mapping of temperature-sensitive mutations of adenoviruses.

2. Physical mapping of temperature-sensitive mutations of adenoviruses.

3. Adenovirus Multiplication: Genetic Relatedness of Tumorigenic Human Adenovirus Types 7, 12, and 18.

4. The physical locations of structural genes in adenovirus DNA.

5. Structural proteins of adenoviruses. I. Purification and characterization of the adenovirus type 2 hexon antigen.

6. A restriction enzyme from Hemophilus influenzae. I. Purification and general properties.

7. Enhancement of adenovirus plaque formation on HeLa cells by magnesium chloride.

8. Isolation of temperature-sensitive mutants of adenovirus type 5.

9. Genetic analysis of adneovirus type 2. IV. Coordinate regulation of polypeptides 80K, IIIa, and V.

10. Adenovirus recombination: physical mapping of crossover events.

Review 1. Current advances and future challenges in Adenoviral vector biology and targeting.

Review 2. Expression of virus-encoded proteinases: functional and structural similarities with cellular enzymes.

3. Characterization of adenovirus particles made by deletion mutants lacking the fiber gene.

4. Polypeptide structure and encoding location of the adenovirus serotype 2 late, nonstructural 33K protein.

5. The sequence of the 3' non-coding region of the hexon mRNA discloses a novel adenovirus gene.

6. Nucleotide sequence analysis of a region of adenovirus 5 DNA encoding a hitherto unidentified gene.

7. Sensitive analysis of genetic heterogeneity of adenovirus types 3 and 7 in the Soviet Union.

8. Adenovirus type 2 endopeptidase: an unusual phosphoprotein enzyme matured by autocatalysis.

9. Physical mapping of adenovirus type 2 temperature-sensitive mutations by restriction endonuclease analysis of interserotypic recombinants.

10. Physical mapping of a large-plaque mutation of adenovirus type 2.