Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 The sequence of the 3' non-coding region of the hexon mRNA discloses a novel adenovirus gene.

Literature DB >> 6259616

The sequence of the 3' non-coding region of the hexon mRNA discloses a novel adenovirus gene.

G Akusjärvi, J Zabielski, M Perricaudet, U Pettersson.

Abstract

We report the sequence of a 1164 nucleotide long DNA segment, located between map positions 59.5 and 62.8 on the adenovirus type 2 genome. The sequence comprises the 701 nucleotides long 3' non-coding region of the hexon mRNA as well as several important processing signals. The sequence revealed unexpectedly that the 3' non-coding region of the hexon mRNA contains a 609 nucleotide long uninterrupted translational reading frame following a potential initiator AUG. A late 14S mRNA, corresponding to the open reading frame, could be identified by S1 nuclease mapping and electronmicroscopy. The mRNA shares a poly(A) addition site with the hexon and pVI mRNAs, and carries a leader sequence which is related, and probably identical, to the tripartite leader, found in late adenovirus mRNAs. The junction between the leader and the body of this novel mRNA is located within the coding part of the hexon gene.

Entities: Chemical Species

Mesh：

Substances：

Year: 1981 PMID： 6259616 PMCID： PMC326664 DOI： 10.1093/nar/9.1.1

Source DB: PubMed Journal: Nucleic Acids Res ISSN： 0305-1048 Impact factor: 16.971

31 in total

1. RNA synthesis and processing in adenovirus-infected cells.

Authors: L Philipson; U Pettersson; U Lindberg; C Tibbetts; B Vennström; T Persson
Journal: Cold Spring Harb Symp Quant Biol Date: 1975

2. Mapping of adenovirus 2 RNA sequences in lytically infected cells and transformed cell lines.

Authors: P A Sharp; P H Gallimore; S J Flint
Journal: Cold Spring Harb Symp Quant Biol Date: 1975

3. Hybridization maps of early and late messenger RNA sequences on the adenovirus type 2 genome.

Authors: U Pettersson; C Tibbetts; L Philipson
Journal: J Mol Biol Date: 1976-03-15 Impact factor: 5.469

4. Detection of specific sequences among DNA fragments separated by gel electrophoresis.

Authors: E M Southern
Journal: J Mol Biol Date: 1975-11-05 Impact factor: 5.469

5. Location and identification of the genes for adenovirus type 2 early polypeptides.

Authors: J B Lewis; J F Atkins; P R Baum; R Solem; R F Gesteland; C W Anderson
Journal: Cell Date: 1976-01 Impact factor: 41.582

6. Structural studies of adenovirus type-2 hexon protein.

Authors: H Jornvall; U Pettersson; L Philipson
Journal: Eur J Biochem Date: 1974-10-01

7. Amount of viral DNA in the genome of cells transformed by adenovirus type 2.

Authors: U Pettersson; J Sambrook
Journal: J Mol Biol Date: 1973-01 Impact factor: 5.469

8. A procedure for the isolation of mammalian messenger ribonucleic acid.

Authors: G Brawerman; J Mendecki; S Y Lee
Journal: Biochemistry Date: 1972-02-15 Impact factor: 3.162

9. Structural properties of adenovirus DNA's.

Authors: A J van der Eb; L W van Kesteren; E F van Bruggen
Journal: Biochim Biophys Acta Date: 1969-06-17

10. Adenovirus DNA. I. Molecular weight and conformation.

Authors: M Green; M Piña; R Kimes; P C Wensink; L A MacHattie; C A Thomas
Journal: Proc Natl Acad Sci U S A Date: 1967-05 Impact factor: 11.205

18 in total

Review 1. Expression of virus-encoded proteinases: functional and structural similarities with cellular enzymes.

Authors: W G Dougherty; B L Semler
Journal: Microbiol Rev Date: 1993-12

2. Nuclei of adenovirus 2-infected cells contain an RNA species that corresponds to an intron excised intact from mRNA precursors.

Authors: R Rosenthal; H J Raskas
Journal: Mol Cell Biol Date: 1985-05 Impact factor: 4.272

10. Physical mapping of adenovirus type 2 temperature-sensitive mutations by restriction endonuclease analysis of interserotypic recombinants.

Authors: J C D'Halluin; C Cousin; P Boulanger
Journal: J Virol Date: 1982-02 Impact factor: 5.103

The sequence of the 3' non-coding region of the hexon mRNA discloses a novel adenovirus gene.

1. RNA synthesis and processing in adenovirus-infected cells.

2. Mapping of adenovirus 2 RNA sequences in lytically infected cells and transformed cell lines.

3. Hybridization maps of early and late messenger RNA sequences on the adenovirus type 2 genome.

4. Detection of specific sequences among DNA fragments separated by gel electrophoresis.

5. Location and identification of the genes for adenovirus type 2 early polypeptides.

6. Structural studies of adenovirus type-2 hexon protein.

7. Amount of viral DNA in the genome of cells transformed by adenovirus type 2.

8. A procedure for the isolation of mammalian messenger ribonucleic acid.

9. Structural properties of adenovirus DNA's.

10. Adenovirus DNA. I. Molecular weight and conformation.

Review 1. Expression of virus-encoded proteinases: functional and structural similarities with cellular enzymes.

2. Nuclei of adenovirus 2-infected cells contain an RNA species that corresponds to an intron excised intact from mRNA precursors.

3. A large inverted repeat sequence overlaps two acceptor splice sites in adenovirus.

4. An unusually long non-coding region in rat lens alpha-crystallin messenger RNA.

5. A 3' co-terminus of two early herpes simplex virus type 1 mRNAs.

6. Sequence of the junction in adenovirus 2-SV40 hybrids: examples of illegitimate recombination.

7. Processing of vimentin occurs during the early stages of adenovirus infection.

8. Polypeptide structure and encoding location of the adenovirus serotype 2 late, nonstructural 33K protein.

9. Adenovirus type 2 endopeptidase: an unusual phosphoprotein enzyme matured by autocatalysis.

10. Physical mapping of adenovirus type 2 temperature-sensitive mutations by restriction endonuclease analysis of interserotypic recombinants.