Literature DB >> 7316764

Chromatographic determination of thiodiglycolic acid - a metabolite of vinyl chloride.

W Dramiński, B Trojanowska.   

Abstract

The determination of thiodiglycolic acid (TDGA) In urine by gas chromatography (GC) is described. The analytical procedure includes addition of internal standard (o-phthalic acid), ethyl acetate extraction, evaporation of the solvent and silylation of TDGA with N-trimethylsilyl-diethylamine in pyridine (1:1). The results are calculated from the ratio of TDGA and internal standard peak heights. The detection limit of the method is 10 mg/l and the coefficient of various is +/- 5%.

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Year:  1981        PMID： 7316764     DOI： 10.1007/bf00319657

Source DB:  PubMed          Journal:  Arch Toxicol        ISSN： 0340-5761            Impact factor:   5.153


  7 in total

1.  The biological fate in rats of vinyl chloride in relation to its oncogenicity.

Authors:  T Green; D E Hathway
Journal:  Chem Biol Interact       Date:  1975-12       Impact factor: 5.192

2.  [Determination of 2 vinylchloride metabolites in urine].

Authors:  G Müller; K Norpoth
Journal:  Naturwissenschaften       Date:  1975-11

3.  Fate of (14C)vinyl chloride after single oral administration in rats.

Authors:  P G Watanabe; G R McGowan; P J Gehring
Journal:  Toxicol Appl Pharmacol       Date:  1976-05       Impact factor: 4.219

4.  Identification of two urine metabolites of vinyl chloride by GC-MS-investigations.

Authors:  G Müller; K Norpoth; R Eckard
Journal:  Int Arch Occup Environ Health       Date:  1976-10-21       Impact factor: 3.015

5.  An analytical method, using GC-MS, for the quantitative determination of urinary thiodiglycolic acid.

Authors:  G Müller; K Norpoth; R H Wickramasinghe
Journal:  Int Arch Occup Environ Health       Date:  1979       Impact factor: 3.015

6.  Determination of thiodiglycolic acid in urine specimens of vinyl chloride exposed workers.

Authors:  G Müller; K Norpoth; E Kusters; K Herweg; E Versin
Journal:  Int Arch Occup Environ Health       Date:  1978-05-12       Impact factor: 3.015

7.  Urinary excretion of thiodiglycollic acid and hepatic content of free thiols in rats at different levels of exposure to vinyl chloride.

Authors:  S Tarkowski; J M Wisniewska-Knypl; J Klimczak; W Dramiński; K Wróblewska
Journal:  J Hyg Epidemiol Microbiol Immunol       Date:  1980
  7 in total
  4 in total

1.  Sensitive flame-photometric-detector analysis of thiodiglycolic acid in urine as a biological monitor of vinyl chloride.

Authors:  Z Y Chen; X R Gu; M Z Cui; X X Zhu
Journal:  Int Arch Occup Environ Health       Date:  1983       Impact factor: 3.015

Review 2.  N-acetyl-S-(2-hydroxyethyl)-L-cysteine as a potential tool in biological monitoring studies? A critical evaluation of possibilities and limitations.

Authors:  N P Vermeulen; J de Jong; E J van Bergen; R T van Welie
Journal:  Arch Toxicol       Date:  1989       Impact factor: 5.153

3.  Influence of exposure mode on vinyl chloride action.

Authors:  R A Jedrychowski; J A Sokal; J Chmielnicka
Journal:  Arch Toxicol       Date:  1984-09       Impact factor: 5.153

4.  A Ratiometric Fluorescent Sensor Based on Dye/Tb (III) Functionalized UiO-66 for Highly Sensitive Detection of TDGA.

Authors:  Yangchun Fan; Xin Jiang; Jie Che; Mingfeng Li; Xuejuan Zhang; Daojiang Gao; Jian Bi; Zhanglei Ning
Journal:  Molecules       Date:  2022-10-03       Impact factor: 4.927
  4 in total

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