Literature DB >> 7316468

A cytogenetic study of 1000 spontaneous abortions.

T Hassold, N Chen, J Funkhouser, T Jooss, B Manuel, J Matsuura, A Matsuyama, C Wilson, J A Yamane, P A Jacobs.   

Abstract

Cytogenetic analysis of 1000 spontaneous abortions showed 463 to have an abnormal chromosome constitution. The proportion of chromosome abnormalities varied with the gestational age of the abortus and the type of tissue cultured but was not significantly different among the five racial groups represented in the study population. It was suggested that differences in the rate of chromosome abnormalities among cytogenetic studies of spontaneous abortions were the result of methodological differences in sample selection rather than real biological variation among study populations. The only factor found to be unequivocally associated with the aetiology of chromosome abnormalities in spontaneous abortions was increasing maternal age in trisomies.

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Year:  1980        PMID： 7316468     DOI： 10.1111/j.1469-1809.1980.tb00955.x

Source DB:  PubMed          Journal:  Ann Hum Genet        ISSN： 0003-4800            Impact factor:   1.670


  123 in total

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