Literature DB >> 7306013

Inhibition by cycloserine of mitochondrial and cytosolic aspartate aminotransferase in isolated rat hepatocytes.

A M Janski, N W Cornell.   

Abstract

Isolated hepatocytes were incubated with L-cycloserine and then treated with digitonin so that mitochondrial and cytosolic fractions were obtained in 5 s. Mitochondrial and total cellular aspartate aminotransferases (EC 2.6.1.1) were inactivated in parallel. The enzyme was also inhibited in isolated mitochondria incubated with L-cycloserine. These results, in contrast with previous reports, indicate that cycloserine reacts equally with mitochondrial and cytosolic aspartate aminotransferases.

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Year:  1981        PMID： 7306013      PMCID： PMC1162844          DOI： 10.1042/bj1941027

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  16 in total

1.  Determination of mitochondrial/cytosolic metabolite gradients in isolated rat liver cells by cell disruption.

Authors:  M E Tischler; P Hecht; J R Williamson
Journal:  Arch Biochem Biophys       Date:  1977-05       Impact factor: 4.013

2.  Effects of aminooxyacetate on the metabolism of isolated liver cells.

Authors:  R Rognstad; D G Clark
Journal:  Arch Biochem Biophys       Date:  1974-04-02       Impact factor: 4.013

3.  The role of hydrogen translocating shuttles during ethanol oxidation in hepatocytes from euthyroid and hyperthyroid rats.

Authors:  L A Hensgens; B J Nieuwenhuis; R van der Meer; A J Meijer
Journal:  Eur J Biochem       Date:  1980

4.  Rate-limiting steps in metabolic pathways.

Authors:  R Rognstad
Journal:  J Biol Chem       Date:  1979-03-25       Impact factor: 5.157

5.  Inhibition of amino acid transaminases by L-cycloserine.

Authors:  D T Wong; R W Fuller; B B Molloy
Journal:  Adv Enzyme Regul       Date:  1973

6.  Functional compartmentation of acetaldehyde oxidation in rat liver.

Authors:  R Parrilla; K Okawa; K O Lindros; U J Zimmerman; K Kobayashi; J R Williamson
Journal:  J Biol Chem       Date:  1974-08-10       Impact factor: 5.157

7.  The reaction of amino-oxyacetate with pyridoxal phosphate-dependent enzymes.

Authors:  R A John; A Charteris
Journal:  Biochem J       Date:  1978-06-01       Impact factor: 3.857

8.  The accumulation of aspartate in the presence of ethanol in rat liver.

Authors:  M Stubbs; H A Krebs
Journal:  Biochem J       Date:  1975-07       Impact factor: 3.857

9.  Acceleration of gluconeogenesis from lactate by lysine (Short Communication).

Authors:  N W Cornell; P Lund; R Hems; H A Krebs
Journal:  Biochem J       Date:  1973-06       Impact factor: 3.857

10.  High-yield preparation of isolated rat liver parenchymal cells: a biochemical and fine structural study.

Authors:  M N Berry; D S Friend
Journal:  J Cell Biol       Date:  1969-12       Impact factor: 10.539
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  2 in total

1.  Selective inhibition of alanine aminotransferase and aspartate aminotransferase in rat hepatocytes.

Authors:  N W Cornell; P F Zuurendonk; M J Kerich; C B Straight
Journal:  Biochem J       Date:  1984-06-15       Impact factor: 3.857

2.  Phosphoenolpyruvate carboxylase identified as a key enzyme in erythrocytic Plasmodium falciparum carbon metabolism.

Authors:  Janet Storm; Sonal Sethia; Gavin J Blackburn; Achuthanunni Chokkathukalam; David G Watson; Rainer Breitling; Graham H Coombs; Sylke Müller
Journal:  PLoS Pathog       Date:  2014-01-16       Impact factor: 6.823
  2 in total

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