Literature DB >> 730396

[Concentration in bone and haematoma of the aminoglycoside antibiotic tobramycin (author's transl)].

W Winkelmann, K P Schulitz, H Knothe, B Schoening.   

Abstract

Tobramycin concentrations were assayed in the rabbit in serum during surgery and in serum, haematoma and bone tissue of the condyle of the femur in the absence of surgery. After a single i. m. injection serum levels were found to be 30% higher initially than in humans, but then dropped at a faster rate to zero. The hardening haematoma appeared to slow penetration of the antibiotic. The concentration in bone tissue was dependent on vascular supply. Surgery did not show any influence on the level of the concentrations.

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Year:  1978        PMID： 730396     DOI： 10.1007/bf01641987

Source DB:  PubMed          Journal:  Infection        ISSN： 0300-8126            Impact factor:   3.553


  13 in total

1.  Pharmacologic studies on tobramycin and comparison with gentamicin.

Authors:  B R Meyers; S Z Hirschman
Journal:  J Clin Pharmacol New Drugs       Date:  1972 Aug-Sep

2.  Determination of antibiotic levels in human bone. I. Gentamicin levels in bone.

Authors:  H Rosin; A M Rosin; J Krämer
Journal:  Infection       Date:  1974       Impact factor: 3.553

3.  Antibiotic penetration of experimental bone hematomas.

Authors:  F C Wilson; J N Worcester; P D Coleman; W E Byrd
Journal:  J Bone Joint Surg Am       Date:  1971-12       Impact factor: 5.284

4.  Structure of nebramycin factor 6, a new aminoglycosidic antibiotic.

Authors:  K F Koch; J A Rhoades
Journal:  Antimicrob Agents Chemother (Bethesda)       Date:  1970

5.  Nebramycin, a new broad-spectrum antibiotic complex. I. Detection and biosynthesis.

Authors:  W M Stark; M M Hoehn; N G Knox
Journal:  Antimicrob Agents Chemother (Bethesda)       Date:  1967

6.  Nebramycin, a new broad-spectrum antibiotic complex. II. Description of Streptomyces tenebrarius.

Authors:  C E Higgins; R E Kastner
Journal:  Antimicrob Agents Chemother (Bethesda)       Date:  1967

7.  Comparative activity of sisomicin, gentamicin, kanamycin, and tobramycin.

Authors:  J A Waitz; E L Moss; C G Drube; M J Weinstein
Journal:  Antimicrob Agents Chemother       Date:  1972-12       Impact factor: 5.191

8.  [Antimicrobial effectiveness of sisomicin. I: In vitro activity of sisomicin compared with gentamicin, tobramycin, amikacin and kanamycin (author's transl)].

Authors:  H H Schassan
Journal:  Infection       Date:  1976       Impact factor: 3.553

9.  Comparative clinical study of tobramycin and gentamicin.

Authors:  J Klastersky; C Hensgens; A Henri; D Daneau
Journal:  Antimicrob Agents Chemother       Date:  1974-02       Impact factor: 5.191

10.  Tobramycin and gentamicin concentrations in the serum of normal and anephric patients.

Authors:  W R Lockwood; J D Bower
Journal:  Antimicrob Agents Chemother       Date:  1973-01       Impact factor: 5.191
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