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Literature DB >> 4790568

Tobramycin and gentamicin concentrations in the serum of normal and anephric patients.

Abstract

The serum half-life of tobramycin was found to be the same as that of gentamicin in patients with similar renal function. The values ranged from 2 hr in normal volunteers to 53.4 hr in anephric patients. Both drugs were readily removed from the serum by the Kiil artificial kidney, with a 70% reduction in serum concentrations during a 12-hr dialysis period.

Entities: Chemical Species

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Year: 1973 PMID： 4790568 PMCID： PMC444371 DOI： 10.1128/AAC.3.1.125

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

18 in total

1. Dose of gentamicin in patients with normal renal function and renal impairment.

Authors: J C Gingell; P M Waterworth
Journal: Br Med J Date: 1968-04-06

2. Preclinical assessment of the antibacterial activity of nebramycin factor 6.

Authors: D A Preston; W E Wick
Journal: Antimicrob Agents Chemother (Bethesda) Date: 1970

3. Correlation of serum creatinine concentration and gentamicin half-life.

Authors: R E Cutler; A M Gyselynck; W P Fleet; A W Forrey
Journal: JAMA Date: 1972-02-21 Impact factor: 56.272

4. Blood levels of ampicillin, kanamycin and gentamicin in the uremic patient.

Authors: G Altmann; B Bogokowsky; G Boner; H E Eliahou
Journal: Isr J Med Sci Date: 1970 Nov-Dec

5. Rapid microassay for circulating nephrotoxic antibiotics.

Authors: L D Sabath; J I Casey; P A Ruch; L L Stumpf; M Finland
Journal: Antimicrob Agents Chemother (Bethesda) Date: 1970

6. Gentamicin dosages for renal insufficiency. Adjustments based on endogenous creatinine clearance and serum creatinine concentration.

Authors: M C McHenry; T L Gavan; R W Gifford; N A Geurkink; R A Van Ommen; M A Town; J G Wagner
Journal: Ann Intern Med Date: 1971-02 Impact factor: 25.391

7. In vitro susceptibility testing with tobramycin.

Authors: S Shadomy; C Kirchoff
Journal: Antimicrob Agents Chemother Date: 1972-05 Impact factor: 5.191

8. In vitro studies of tobramycin, an aminoglycoside antibiotic.

Authors: J Dienstag; H C Neu
Journal: Antimicrob Agents Chemother Date: 1972-01 Impact factor: 5.191

9. In vitro evaluation of tobramycin, a new aminoglycoside antibiotic.

Authors: M E Levison; R Knight; D Kaye
Journal: Antimicrob Agents Chemother Date: 1972-05 Impact factor: 5.191

10. Evaluation of the in vitro activity of tobramycin as compared with that of gentamicin sulfate.

Authors: W H Traub; E A Raymond
Journal: Appl Microbiol Date: 1972-01

25 in total

Review 1. Critical compilation of terminal half-lives, percent excreted unchanged, and changes of half-life in renal and hepatic dysfunction for studies in humans with references.

Authors: L A Pagliaro; L Z Benet
Journal: J Pharmacokinet Biopharm Date: 1975-10

2. Pharmacokinetics of tobramycin in patients with stable renal impairment, patients undergoing peritoneal dialysis, and patients on chronic hemodialysis.

Authors: G Jaffe; B R Meyers; S Z Hirschman
Journal: Antimicrob Agents Chemother Date: 1974-06 Impact factor: 5.191

Review 3. Antibacterial Drugs today: II.

Authors: A P Ball; J A Gray; J M Murdoch
Journal: Drugs Date: 1975 Impact factor: 9.546

4. Effect of peritoneal dialysis on serum levels of tobramycin and clindamycin.

Authors: R F Malacoff; F O Finkelstein; V T Andriole
Journal: Antimicrob Agents Chemother Date: 1975-11 Impact factor: 5.191

5. Renal extraction of gentamicin in anesthetized dogs.

Authors: P J Chiu; A Brown; G Miller; J F Long
Journal: Antimicrob Agents Chemother Date: 1976-08 Impact factor: 5.191

6. Drug kinetics and artificial kidneys.

Authors: T B Gibson; H A Nelson
Journal: Clin Pharmacokinet Date: 1977 Nov-Dec Impact factor: 6.447

7. Blood, brain, and cerebrospinal fluid concentrations of several antibiotics in rabbits with intact and inflamed meninges.

Authors: T R Beam; J C Allen
Journal: Antimicrob Agents Chemother Date: 1977-12 Impact factor: 5.191