Literature DB >> 730161

Isozyme variations in acetaldehyde dehydrogenase (e.c.1.2.1.3) in human tissues.

S Harada, D P Agarwal, H W Goedde.   

Abstract

NAD-dependent acetaldehyde dehydrogenase (ALDH) of human tissues was investigated by electrophoresis and enzyme assay. ALDH is located mainly in the liver and kidney. The isozymes consist of at least six different components. Five different phenotypes were found in a total of 68 human liver and kidney specimens. It is likely that three isozyme sets are concerned in determining ALDH types. The distribution of various phenotypes of ALDH isozyme sets is presented.

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Year:  1978        PMID： 730161     DOI： 10.1007/bf00295411

Source DB:  PubMed          Journal:  Hum Genet        ISSN： 0340-6717            Impact factor:   4.132


  7 in total

1.  PHOSPHOGLUCOMUTASE POLYMORPHISM IN MAN.

Authors:  N SPENCER; D A HOPKINSON; H HARRIS
Journal:  Nature       Date:  1964-11-21       Impact factor: 49.962

2.  Aldehyde dehydrogenase activity in a rat hepatoma.

Authors:  R N Feinstein; E C Cameron
Journal:  Biochem Biophys Res Commun       Date:  1972-09-05       Impact factor: 3.575

3.  Mechanism of the inhibition of aldehyde dehydrogenase in vivo by disulfiram and diethyldithiocarbamate.

Authors:  R A Deitrich; V G Erwin
Journal:  Mol Pharmacol       Date:  1971-05       Impact factor: 4.436

4.  Studies on the properties of the human alcohol dehydrogenase isozymes determined by the different loci ADH1, ADH2, ADH3.

Authors:  M Smith; D A Hopkinson; H Harris
Journal:  Ann Hum Genet       Date:  1973-07       Impact factor: 1.670

5.  Developmental changes and polymorphism in human alcohol dehydrogenase.

Authors:  M Smith; D A Hopkinson; H Harris
Journal:  Ann Hum Genet       Date:  1971-02       Impact factor: 1.670

6.  Human liver alcohol dehydrogenase isoenzyme variations. Improved separation methods using prolonged high voltage starch-gel electrophoresis and isoelectric focusing.

Authors:  S Harada; D P Agarwal; H W Goedde
Journal:  Hum Genet       Date:  1978-01-19       Impact factor: 4.132

7.  Liver alcohol dehydrogenase in Japanese: high population frequency of atypical form and its possible role in alcohol sensitivity.

Authors:  G Stamatoyannopoulos; S H Chen; M Fukui
Journal:  Am J Hum Genet       Date:  1975-11       Impact factor: 11.025
  7 in total
  16 in total

1.  Effects of H2-receptor antagonists on ethanol metabolism in Japanese volunteers.

Authors:  E Tanaka; K Nakamura
Journal:  Br J Clin Pharmacol       Date:  1988-07       Impact factor: 4.335

2.  A revised indirect estimate of mutation rates in Amerindians.

Authors:  J V Neel; H W Mohrenweiser; E D Rothman; J M Naidu
Journal:  Am J Hum Genet       Date:  1986-05       Impact factor: 11.025

3.  Racial differences in alcohol sensitivity: a new hypothesis.

Authors:  H W Goedde; S Harada; D P Agarwal
Journal:  Hum Genet       Date:  1979-10-02       Impact factor: 4.132

Review 4.  Ethnic differences in drug metabolism.

Authors:  W Kalow
Journal:  Clin Pharmacokinet       Date:  1982 Sep-Oct       Impact factor: 6.447

5.  Enzymatic activity of atypical Oriental types of aldehyde dehydrogenases.

Authors:  A Yoshida; V Davé
Journal:  Biochem Genet       Date:  1985-08       Impact factor: 1.890

6.  Enhancement of aldehyde dehydrogenase activity in human and rat hepatocyte cultures by 3-methylcholanthrene.

Authors:  M Marselos; S C Strom; G Michalopoulos
Journal:  Cell Biol Toxicol       Date:  1986-06       Impact factor: 6.691

7.  Subcellular localization of aldehyde dehydrogenase isozymes in human liver.

Authors:  S Takase; M Tsutsumi; A Takada
Journal:  Gastroenterol Jpn       Date:  1989-02

8.  Increased excretion of harman by alcoholics depends on events of their life history and the state of the liver.

Authors:  H Rommelspacher; H Damm; L Schmidt; G Schmidt
Journal:  Psychopharmacology (Berl)       Date:  1985       Impact factor: 4.530

9.  Research on alcohol metabolism among Asians and its implications for understanding causes of alcoholism.

Authors:  R F Suddendorf
Journal:  Public Health Rep       Date:  1989 Nov-Dec       Impact factor: 2.792

Review 10.  Aldehyde dehydrogenase 2 in aplastic anemia, Fanconi anemia and hematopoietic stem cells.

Authors:  Lauren D Van Wassenhove; Daria Mochly-Rosen; Kenneth I Weinberg
Journal:  Mol Genet Metab       Date:  2016-07-15       Impact factor: 4.797
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