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Literature DB >> 624549

Human liver alcohol dehydrogenase isoenzyme variations. Improved separation methods using prolonged high voltage starch-gel electrophoresis and isoelectric focusing.

Abstract

Human liver alcohol dehydrogenase isozyme patterns were studied using prolonged high voltage starch-gel electrophoresis and gel-slab isoelectric focusing. Homo- and heterodimers of ADH2 locus were easily distinguished from each other. The gene frequencies of ADH2 2 and ADH2 3 in 46 random liver samples from Germany were found to be 0.044 and 0.424 respectively.

Entities: Chemical Gene Species

Mesh：

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Year: 1978 PMID： 624549 DOI： 10.1007/bf00272304

Source DB: PubMed Journal: Hum Genet ISSN： 0340-6717 Impact factor: 4.132

7 in total

1. Identification of a distinctive molecular form of alcohol dehydrogenase in human livers with high activity.

Authors: T K Li; L J Magnes
Journal: Biochem Biophys Res Commun Date: 1975-03-03 Impact factor: 3.575

2. Studies on the subunit structure and molecular size of the human alcohol dehydrogenase isozymes determined by the different loci, ADH1, ADH2, and ADH3.

Authors: M Smith; D A Hopkinson; H Harris
Journal: Ann Hum Genet Date: 1973-04 Impact factor: 1.670

3. Alcohol dehydrogenase isozymes in adult human stomach and liver: evidence for activity of the ADH 3 locus.

Authors: M Smith; D A Hopkinson; H Harris
Journal: Ann Hum Genet Date: 1972-03 Impact factor: 1.670

4. Structural studies of alcohol dehydrogenase from human liver.

Authors: H Jörnvall; R Pietruszko
Journal: Eur J Biochem Date: 1972-02-15

5. Heterogeneity and polymorphism of human-liver alcohol dehydrogenase.

Authors: T M Schenker; L J Teeple; J P Von Wartburg
Journal: Eur J Biochem Date: 1971-12

6. Developmental changes and polymorphism in human alcohol dehydrogenase.

Authors: M Smith; D A Hopkinson; H Harris
Journal: Ann Hum Genet Date: 1971-02 Impact factor: 1.670

7. Liver alcohol dehydrogenase in Japanese: high population frequency of atypical form and its possible role in alcohol sensitivity.

Authors: G Stamatoyannopoulos; S H Chen; M Fukui
Journal: Am J Hum Genet Date: 1975-11 Impact factor: 11.025

7 in total

11 in total

1. Genotypes for aldehyde dehydrogenase deficiency and alcohol sensitivity. The inactive ALDH2(2) allele is dominant.

Authors: D W Crabb; H J Edenberg; W F Bosron; T K Li
Journal: J Clin Invest Date: 1989-01 Impact factor: 14.808

2. Racial differences in alcohol sensitivity: a new hypothesis.

Authors: H W Goedde; S Harada; D P Agarwal
Journal: Hum Genet Date: 1979-10-02 Impact factor: 4.132

Review 3. Ethnic differences in drug metabolism.

Authors: W Kalow
Journal: Clin Pharmacokinet Date: 1982 Sep-Oct Impact factor: 6.447

4. Liver alcohol dehydrogenase and aldehyde dehydrogenase in the Japanese: isozyme variation and its possible role in alcohol intoxication.

Authors: S Harada; S Misawa; D P Agarwal; H W Goedde
Journal: Am J Hum Genet Date: 1980-01 Impact factor: 11.025

5. Isozyme variations in acetaldehyde dehydrogenase (e.c.1.2.1.3) in human tissues.

Authors: S Harada; D P Agarwal; H W Goedde
Journal: Hum Genet Date: 1978-10-31 Impact factor: 4.132

6. Research on alcohol metabolism among Asians and its implications for understanding causes of alcoholism.

Authors: R F Suddendorf
Journal: Public Health Rep Date: 1989 Nov-Dec Impact factor: 2.792

7. Polymorphism of human liver alcohol dehydrogenase: identification of ADH2 2-1 and ADH2 2-2 phenotypes in the Japanese by isoelectric focusing.

Authors: S J Yin; W F Bosron; T K Li; K Ohnishi; K Okuda; H Ishii; M Tsuchiya
Journal: Biochem Genet Date: 1984-02 Impact factor: 1.890