Literature DB >> 7297653

Concurrent occurrence of elevated ketone body and depressed carnitine level in underfed guinea-pigs.

A Sandor, J Kerner, I Alkonyi.   

Abstract

Food ingestion of male guinea-pigs was restricted to 10 g/day. Total carnitine content of liver of the underfed animals fell to 3.75 mumoles per liver (46.1% of control). Serum level of total carnitine was 35.0 nmoles/ml (64.4%) in the underfed animals while they developed high ketonemia, 384.2 nmoles/ml (555.2%). In "restricted' animals the carnitine levels also decreased in the muscles.

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Year:  1981        PMID： 7297653     DOI： 10.1007/bf01971761

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  12 in total

1.  An improved and simplified radioisotopic assay for the determination of free and esterified carnitine.

Authors:  J D McGarry; D W Foster
Journal:  J Lipid Res       Date:  1976-05       Impact factor: 5.922

2.  Cofactor requirements of gamma-butyrobetaine hydroxylase from rat liver.

Authors:  G Lindstedt; S Lindstedt
Journal:  J Biol Chem       Date:  1970-08-25       Impact factor: 5.157

3.  Metabolic profiles of three fiber types of skeletal muscle in guinea pigs and rabbits.

Authors:  J B Peter; R J Barnard; V R Edgerton; C A Gillespie; K E Stempel
Journal:  Biochemistry       Date:  1972-07-04       Impact factor: 3.162

4.  Aspects of carnitine ester metabolism in sheep liver.

Authors:  A M Snoswell; G D Henderson
Journal:  Biochem J       Date:  1970-08       Impact factor: 3.857

Review 5.  Regulation of hepatic fatty acid oxidation and ketone body production.

Authors:  J D McGarry; D W Foster
Journal:  Annu Rev Biochem       Date:  1980       Impact factor: 23.643

6.  Carnitine palmitoyltransferase I. The site of inhibition of hepatic fatty acid oxidation by malonyl-CoA.

Authors:  J D McGarry; G F Leatherman; D W Foster
Journal:  J Biol Chem       Date:  1978-06-25       Impact factor: 5.157

7.  The syndrome of systemic carnitine deficiency. Clinical, morphologic, biochemical, and pathophysiologic features.

Authors:  G Karpati; S Carpenter; A G Engel; G Watters; J Allen; S Rothman; G Klassen; O A Mamer
Journal:  Neurology       Date:  1975-01       Impact factor: 9.910

8.  Carnitine biosynthesis. beta-Hydroxylation of trimethyllysine by an alpha-ketoglutarate-dependent mitochondrial dioxygenase.

Authors:  J D Hulse; S R Ellis; L M Henderson
Journal:  J Biol Chem       Date:  1978-03-10       Impact factor: 5.157

9.  Fatal systemic carnitine deficiency with lipid storage in skeletal muscle, heart, liver and kidney.

Authors:  G Boudin; J Mikol; A Guillard; A G Engel
Journal:  J Neurol Sci       Date:  1976-12       Impact factor: 3.181

10.  Role of carnitine in hepatic ketogenesis.

Authors:  J D McGarry; C Robles-Valdes; D W Foster
Journal:  Proc Natl Acad Sci U S A       Date:  1975-11       Impact factor: 11.205
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  1 in total

1.  Combined effect of ascorbic acid deficiency and underfeeding on the hepatic carnitine level in guinea-pigs.

Authors:  A Sandor; G Kispal; J Kerner; I Alkonyi
Journal:  Experientia       Date:  1983-05-15
  1 in total

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