Literature DB >> 729735

Kinetics and inotropic action of probenecid in guinea-pig heart in vitro.

R R Erttmann.   

Abstract

Probenecid (100-750 microgram . ml-1) was found to inhibit cardiac contraction force in untreated and digoxin-treated (100 microgram . ml-1) isolated right guinea-pig atrium in vitro by a reversible process, without influencing beating frequency. At low concentrations (1.5--60 microgram . ml-1), 14C-probenecid was accumulated into right atrium by an oxygen-dependent process. Correlation between uptake and negative inotropic action of probenecid could not be found.

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Year:  1978        PMID： 729735     DOI： 10.1007/bf02034712

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  12 in total

1.  Interaction of probenecid with digitoxin metabolism in rats.

Authors:  K H Damm; R Erttmann
Journal:  Toxicol Appl Pharmacol       Date:  1975-08       Impact factor: 4.219

2.  The physiological disposition of probenecid, including renal clearance, in man, studied by an improved method for its estimation in biological material.

Authors:  P G DAYTON; T F YU; W CHEN; L BERGER; L A WEST; A B GUTMAN
Journal:  J Pharmacol Exp Ther       Date:  1963-06       Impact factor: 4.030

3.  Uptake of probenecid by rat liver slices.

Authors:  P L Gigon; A M Guarino
Journal:  Biochem Pharmacol       Date:  1970-09       Impact factor: 5.858

4.  The effect of probenecid on the in vitro absorption of cardiac glycosides.

Authors:  K H Damm; C Woermann
Journal:  Eur J Pharmacol       Date:  1974-09       Impact factor: 4.432

5.  [The effect of some drugs on the protein binding of phenol red and digitoxin].

Authors:  R Beeck; W Braun; K H Damm; R Erttmann; T Gerhardt
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1972       Impact factor: 3.000

6.  Probenecid and hepatic transport of 3-H-ouabain in rats.

Authors:  R Erttmann; K H Damm
Journal:  Arch Int Pharmacodyn Ther       Date:  1974-10

7.  Effects of phenolsulfonphthalein and probenecid on the uptake and utilization of citrate and -ketoglutarate by kidney, in vitro.

Authors:  A Pakarinen; L Runeberg
Journal:  Biochem Pharmacol       Date:  1969-10       Impact factor: 5.858

8.  Uptake and utilization of citrate and alpha-ketoglutarate by liver slices. Effects of phenolsulfonphthalein and probenecid.

Authors:  A Pakarinen
Journal:  Ann Med Exp Biol Fenn       Date:  1971

9.  Drug interactions in intestinal absorption of 3H-digitoxin in rats.

Authors:  W Braun; K H Damm
Journal:  Experientia       Date:  1976-05-15

10.  Probenecid-induced effects on bile flow and biliary excretion of 3H-ouabain.

Authors:  R R Erttmann; K H Damm
Journal:  Arch Int Pharmacodyn Ther       Date:  1976-09
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  1 in total

1.  Mechanisms of force inhibition by halothane and isoflurane in intact rat cardiac muscle.

Authors:  P J Hanley; D S Loiselle
Journal:  J Physiol       Date:  1998-01-01       Impact factor: 5.182
  1 in total

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