Literature DB >> 729710

Control of obesity in Avy/a mice by 5alpha-androstan-17-one.

T T Yen, J A Allan, D V Pearson, J M Acton.   

Abstract

Treating VY/WfL-Avy/a mice with 5 alpha-androston-17-one, a mammalian glucose-6-phosphate dehydrogenase inhibitor, prevented the mice from becoming obese. The weight difference between treated and control Avy/a mice was mainly due to a decreased accumulation of triacylglycerol. The compound did not suppress appetite, had no detectable toxicity and did not affect the lipogenesis rates in the liver and carcass. The weight-controlling effect of 5alpha-androstan-17-one in Avy/a mice was reversible upon withdrawal of treatment.

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Year:  1978        PMID： 729710     DOI： 10.1007/bf02034660

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  4 in total

1.  An analysis of the relationships among obesity, plasma insulin and hepatic lipogenic enzymes in "viable yellow obese" mice (Avy/a).

Authors:  T T Yen; M M Greenberg; P L Yu; D V Pearson
Journal:  Horm Metab Res       Date:  1976-05       Impact factor: 2.936

2.  On the specificity of steroid interaction with mammary glucose 6-phosphate dehydrogenase.

Authors:  R Raineri; H R Levy
Journal:  Biochemistry       Date:  1970-05-26       Impact factor: 3.162

3.  Triacylglycerol contents and in vivo lipogenesis of ob/ob, db/db and Avy/a mice.

Authors:  T T Yen; J A Allan; P L Yu; M A Acton; D V Pearson
Journal:  Biochim Biophys Acta       Date:  1976-08-23

4.  Prevention of obesity in Avy/a mice by dehydroepiandrosterone.

Authors:  T T Yen; J A Allan; D V Pearson; J M Acton; M M Greenberg
Journal:  Lipids       Date:  1977-05       Impact factor: 1.880
  4 in total

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