| Literature DB >> 140989 |
T T Yen, J A Allan, D V Pearson, J M Acton, M M Greenberg.
Abstract
Dehydroepiandrosterone, a mammalian glucose-6-phosphate dehydrogenase inhibitor, prevented Avy/a mice from becoming obese. Decreased accumulation of triacylglycerol accounted for a large portion of the weight difference between treated and control Avy/a mice. Hepatic lipogenesis as measured by 3H2O incorporation into total lipid was less in the dehydroepiandrosterone-treated mice. Dehydroepiandrosterone did not suppress appetite and had no apparent toxic effects at the doses used, and its weight controlling effects were reversible upon withdrawal of treatment.Entities:
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Year: 1977 PMID： 140989 DOI： 10.1007/bf02533624
Source DB: PubMed Journal: Lipids ISSN： 0024-4201 Impact factor: 1.880