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Literature DB >> 7295514

Effects of nandrolone decanoate on the toxicity and anti-tumour action of CCNU and FU in murine tumours.

Abstract

Pre-treatment with the anabolic steroid nandrolone decanoate (ND) increases the LD50 of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) and 5-Fluorouracil (FU) in NMRI mice. Administration of ND did not affect the anti-tumour action of CCNU against a transplantable mouse adenocarcinoma of the colon (MAC 13) or the anti-tumour action of FU against MAC 26. In both tumour lines ND had no significant effect on tumour growth. These data suggest that an increase in the anti-tumour selectivity of these agents may be produced by pre-treatment with ND.

Entities: Chemical Disease Species

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Year: 1981 PMID： 7295514 PMCID： PMC2010805 DOI： 10.1038/bjc.1981.228

Source DB: PubMed Journal: Br J Cancer ISSN： 0007-0920 Impact factor: 7.640

12 in total

1. Breast cancer; a new approach to therapy.

Authors: G W WATSON; R L TURNER
Journal: Br Med J Date: 1959-05-23

2. A comparison of myotrophic and androgenic activities of testosterone propionate with 19-nortestosterone and its esters.

Authors: L E BARNES; R O STAFFORD; M E GUILD; L C THOLE; K J OLSON
Journal: Endocrinology Date: 1954-07 Impact factor: 4.736

3. Myotrophic activity of 19-nortestosterone and other steroids determined by modified levator ani muscle method.

Authors: L G HERSHBERGER; E G SHIPLEY; R K MEYER
Journal: Proc Soc Exp Biol Med Date: 1953-05

4. Improvement of life quality in cancer patients undergoing chemotherapy.

Authors: G A Edelstyn; K D MacRae; F M MacDonald
Journal: Clin Oncol Date: 1979-03

5. Acceleration of granulopoietic recovery by androgenic steroids in mice made neutropenic by cytotoxic drugs.

Authors: K B Udupa; K R Reissmann
Journal: Cancer Res Date: 1974-10 Impact factor: 12.701

6. In vitro proliferation of haemopoietic cells in the presence of adherent cell layers. II. Differential effect of adherent cell layers derived from various organs.

Authors: J Reimann; H Burger
Journal: Exp Hematol Date: 1979-01 Impact factor: 3.084

Effects of nandrolone decanoate on the toxicity and anti-tumour action of CCNU and FU in murine tumours.

1. Breast cancer; a new approach to therapy.

2. A comparison of myotrophic and androgenic activities of testosterone propionate with 19-nortestosterone and its esters.

3. Myotrophic activity of 19-nortestosterone and other steroids determined by modified levator ani muscle method.

4. Improvement of life quality in cancer patients undergoing chemotherapy.

5. Acceleration of granulopoietic recovery by androgenic steroids in mice made neutropenic by cytotoxic drugs.

6. In vitro proliferation of haemopoietic cells in the presence of adherent cell layers. II. Differential effect of adherent cell layers derived from various organs.

7. Transplantable colon tumors as chemotherapy screening models.

8. Chemotherapy of transplanted adenocarcinomas of the colon in mice.

9. Transplantation of adenocarcinomas of the colon in mice.

10. Anabolic steroids and bone marrow toxicity during therapy with methotrexate.

1. Characterisation and chemosensitivity of a well-differentiated murine transplantable adenocarcinoma of the colon.

2. Simple ammonium salts acting on sigma-1 receptors yield potential treatments for cancer and depression.