Literature DB >> 4343678

Anabolic steroids and bone marrow toxicity during therapy with methotrexate.

R G Rawbone, K D Bagshawe.   

Abstract

The effect of the anabolic steroids nandrolone decanoate and oxymetholone on the peripheral blood haemoglobin, total leucocyte and platelet counts was studied in a controlled trial in which patients received standardized chemotherapy for one form of malignant disease. The results indicate that these agents have no protective effect on bone marrow suppression during cytotoxic chemotherapy. It was observed that the time interval between the initial nadir total leucocyte count and the return to pre-treatment values in those patients receiving the anabolic steroids was significantly shorter than in the control group.

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Year:  1972        PMID： 4343678      PMCID： PMC2008626          DOI： 10.1038/bjc.1972.52

Source DB:  PubMed          Journal:  Br J Cancer        ISSN： 0007-0920            Impact factor:   7.640


  12 in total

1.  Stimulation of erythropoiesis by androgenic hormones.

Authors:  B J KENNEDY
Journal:  Ann Intern Med       Date:  1962-12       Impact factor: 25.391

2.  Androgens and erythropoiesis. I. Preliminary clinical observations.

Authors:  F H GARDNER; J C PRINGLE
Journal:  Arch Intern Med       Date:  1961-06

3.  Breast cancer; a new approach to therapy.

Authors:  G W WATSON; R L TURNER
Journal:  Br Med J       Date:  1959-05-23

4.  A neutrophil cycle in healthy individuals.

Authors:  A A Morley
Journal:  Lancet       Date:  1966-12-03       Impact factor: 79.321

5.  Leukopoietic stimulation by testosteron in cancer patients treated by chemotherapy and irradiation.

Authors:  Y Horn; E Robinson; A Hochman
Journal:  Radiol Clin Biol       Date:  1968

6.  Cyclophosphamide-induced cyclical neutropenia. An animal model of a human periodic disease.

Authors:  A Morley; F Stohlman
Journal:  N Engl J Med       Date:  1970-03-19       Impact factor: 91.245

7.  Computer simulation of granulopoiesis: normal and impaired granulopoiesis.

Authors:  E A King-Smith; A Morley
Journal:  Blood       Date:  1970-08       Impact factor: 22.113

8.  The normal haemoglobin level.

Authors:  L Garby
Journal:  Br J Haematol       Date:  1970-10       Impact factor: 6.998

9.  Anabolic androgenic steroids in the treatment of acquired aplastic anemia.

Authors:  L Sanchez-Medal; A Gomez-Leal; L Duarte; M Guadalupe Rico
Journal:  Blood       Date:  1969-09       Impact factor: 22.113

10.  Aplastic anaemia, acute myeloblastic leukaemia, and oxymetholone.

Authors:  I W Delamore; C G Geary
Journal:  Br Med J       Date:  1971-06-26
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  5 in total

1.  Iliopsoas hypertrophy mimicking acute abdomen in a bodybuilder.

Authors:  J Zeiss; R R Smith; A M Taha
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Review 2.  [Hematopoietic stimulation for enhanced bone marrow regeneration after chemotherapy (author's transl)].

Authors:  L Labedzki; D Noack
Journal:  Klin Wochenschr       Date:  1980-03-03

Review 3.  Androgen receptor (AR) pathophysiological roles in androgen-related diseases in skin, bone/muscle, metabolic syndrome and neuron/immune systems: lessons learned from mice lacking AR in specific cells.

Authors:  Chawnshang Chang; Shuyuan Yeh; Soo Ok Lee; Ta-Min Chang
Journal:  Nucl Recept Signal       Date:  2013-08-19

4.  Neutropenia with impaired host defense against microbial infection in mice lacking androgen receptor.

Authors:  Kuang-Hsiang Chuang; Saleh Altuwaijri; Gonghui Li; Jiann-Jyh Lai; Chin-Yi Chu; Kuo-Pao Lai; Hung-Yun Lin; Jong-Wei Hsu; Peter Keng; Ming-Chi Wu; Chawnshang Chang
Journal:  J Exp Med       Date:  2009-05-04       Impact factor: 14.307

5.  Effects of nandrolone decanoate on the toxicity and anti-tumour action of CCNU and FU in murine tumours.

Authors:  M C Bibby; J A Double; M A Mughal
Journal:  Br J Cancer       Date:  1981-10       Impact factor: 7.640
  5 in total

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