Literature DB >> 7294879

[8-Methoxypsoralen (8-MOP)-a new galenic form and its relation to 8-MOP serum levels (author's transl)].

V Nitsche, M Raff, H Bardach.   

Abstract

A bioequivalence study was performed with two different 8-MOP preparations. Thirty-eight patients participated in the investigation. We compared a product already marketed containing a micronized powder in hard gelatine capsules with a new product in soft gelatine capsules containing the 8-MOP in a solution. With the new galenic preparation the serum level obtained was 3.2 (P less than or equal to 0.01) times higher than with the old product. Thus, the improved resorption out of the solution was mainly responsible for these results.

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Year:  1981        PMID: 7294879     DOI: 10.1007/bf00417383

Source DB:  PubMed          Journal:  Arch Dermatol Res        ISSN: 0340-3696            Impact factor:   3.017


  15 in total

Review 1.  [Oral photochemotherapy (author's transl)].

Authors:  F Gschnait
Journal:  Wien Klin Wochenschr Suppl       Date:  1977

2.  Difference in the efficiency of two delivery forms of 8-methoxypsoralen.

Authors:  M K Polano; A A Schothorst
Journal:  Dermatologica       Date:  1977

3.  Photoinactivation of skin fibroblasts by fractionated treatment with 8-methoxypsoralen and UVA.

Authors:  J Pohl; E Christophers
Journal:  J Invest Dermatol       Date:  1979-08       Impact factor: 8.551

4.  Photochemotherapy of psoriasis with oral methoxsalen and longwave ultraviolet light.

Authors:  J A Parrish; T B Fitzpatrick; L Tanenbaum; M A Pathak
Journal:  N Engl J Med       Date:  1974-12-05       Impact factor: 91.245

5.  Determination of 8-methoxypsoralen in plasma by electron capture gas chromatography.

Authors:  H Ehrsson; S Eksborg; I Wallin; N Kållberg; G Swanbeck
Journal:  J Chromatogr       Date:  1977-10-11

6.  [Photochemotherapy of psoriasis: clinical experiences with 152 patients (author's transl)].

Authors:  K Wolff; H Hönigsmann; F Gschnait; K Konrad
Journal:  Dtsch Med Wochenschr       Date:  1975-11-28       Impact factor: 0.628

7.  Plasma levels of 8-methoxypsoralen determined by high-pressure liquid chromatography in psoriatic patients ingesting drug from two manufacturers.

Authors:  B Ljunggren; D M Carter; J Albert; T Reid
Journal:  J Invest Dermatol       Date:  1980-01       Impact factor: 8.551

8.  Pharmacokinetics and metabolite-pattern of 8-methoxypsoralen in man following oral administration as compared to the pharmacokinetics in rat and dog.

Authors:  U Busch; J Schmid; F W Koss; H Zipp; A Zimmer
Journal:  Arch Dermatol Res       Date:  1978-08-28       Impact factor: 3.017

9.  Photochemotherapy of psoriasis with relevance to 8-methoxypsoralen plasma level and low intensity irradiation.

Authors:  P Thune; G Volden
Journal:  Acta Derm Venereol       Date:  1977       Impact factor: 4.437

10.  Pharmacokinetic and clinical comparison of two 8-methoxypsoralen brands.

Authors:  K E Andersen; T Menne; M Gammeltoft; N Hjorth; E Larsen; P Solgaard
Journal:  Arch Dermatol Res       Date:  1980       Impact factor: 3.017

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  4 in total

1.  Comparison of serum levels and clinical results of PUVA therapy with three different dosage forms of 8-methoxypsoralen.

Authors:  A H Siddiqui; L M Stolk; R H Cormane
Journal:  Arch Dermatol Res       Date:  1984       Impact factor: 3.017

2.  Hypertrichosis: a side-effect of PUVA therapy.

Authors:  F H Rampen
Journal:  Arch Dermatol Res       Date:  1985       Impact factor: 3.017

Review 3.  Clinical pharmacokinetics of methoxsalen and other psoralens.

Authors:  F A de Wolff; T V Thomas
Journal:  Clin Pharmacokinet       Date:  1986 Jan-Feb       Impact factor: 6.447

4.  Normalization of defective interleukin 1 and interleukin 2 production in patients with pemphigus vulgaris following chrysotherapy.

Authors:  E Blitstein-Willinger
Journal:  Clin Exp Immunol       Date:  1985-12       Impact factor: 4.330

  4 in total

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