| Literature DB >> 7291042 |
F B Jolicoeur, A Barbeau, F Rioux, R Quirion, S St-Pierre.
Abstract
Neurobehavioral effects of neurotensin and structural analogues in which tyrosine in position 11 was replaced by either its d-isomer [D-Tyr11]-NT, phenylalanine [Phe11]-NT or D-phenylalanine [D-Phe11]-NT were studied. Results demonstrate that whereas neurotensin and [Phe11]-NT significantly decreased motor activity in rats, [D-Tyr11]-NT and [D-Phe11]-NT produced a marked and significant increase in activity. Such dichotomous action between analogues was not found for the hypothermic and muscular relaxation effects of neurotensin.Entities:
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Year: 1981 PMID： 7291042 DOI： 10.1016/s0196-9781(81)80031-9
Source DB: PubMed Journal: Peptides ISSN： 0196-9781 Impact factor: 3.750