| Literature DB >> 7286992 |
Abstract
Satellite DNA isolated from female Elapid snakes contains nucleotide sequences which are quantitatively derived from the W sex-determining chromosome. Certain of these sequences are highly conserved in vertebrates, including mammals, where they are arranged in a sex-specific pattern in Southern blots. Sex reversed mice (Sxr) show a DNA arrangement of these sequences in conformity with their phenotypic sex, suggesting that this DNA is closely connected with the determination of sex. In situ hybridization of the snake sequences with mouse chromosomes reveals a concentration of related DNA at the proximal tip of the mouse Y chromosome. This possible nature and significance of these observations is discussed.Entities:
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Year: 1981 PMID: 7286992 DOI: 10.1007/BF00284148
Source DB: PubMed Journal: Hum Genet ISSN: 0340-6717 Impact factor: 4.132