Literature DB >> 7282914

Contraction of guinea pig ileal smooth muscle by acetyl glyceryl ether phosphorylcholine.

S R Findlay, L M Lichtenstein, D J Hanahan, R N Pinckard.   

Abstract

Acetyl glyceryl ether phosphorylcholine (AGEPC) is a chemical that has the biological activity of what was formerly termed platelet-activating factor. We report here that synthetic AGEPC induces the contraction of guinea pig ileal smooth muscle. Antagonists of histamine, acetylcholine, and slow-reacting substances (SRS) do not block AGEPC-induced contraction. These responses were long lasting, resistant to washing, and displayed complete agonist specific desensitization. Histamine- and SRS-induced contractions were unaffected by AGEPC. These studies show that AGEPC has the potential to produce a component of anaphylactically induced smooth muscle contraction.

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Year:  1981        PMID： 7282914     DOI： 10.1152/ajpcell.1981.241.3.C130

Source DB:  PubMed          Journal:  Am J Physiol        ISSN： 0002-9513


  25 in total

1.  Increased hepatic platelet activating factor (PAF) and PAF receptors in carbon tetrachloride induced liver cirrhosis.

Authors:  Y Yang; E M Nemoto; S A K Harvey; V M Subbotin; C R Gandhi
Journal:  Gut       Date:  2004-06       Impact factor: 23.059

2.  Effect of increased hepatic platelet activating factor and its receptor portal hypertension in CCl4-induced liver cirrhosis.

Authors:  Yong-Ping Yang; Xue-Mei Ma; Chun-Ping Wang; Jun Han; Yin-Ying Lu; Yi Xiang; Shu-Hui Su; Yong-Yi Feng
Journal:  World J Gastroenterol       Date:  2006-02-07       Impact factor: 5.742

3.  Characterization of a platelet-activating factor acetylhydrolase secreted by the nematode parasite Nippostrongylus brasiliensis.

Authors:  M E Grigg; K Gounaris; M E Selkirk
Journal:  Biochem J       Date:  1996-07-15       Impact factor: 3.857

4.  Effect of platelet activating factor on guinea-pig papillary muscle.

Authors:  G Camussi; G Alloatti; G Montrucchio; M Meda; G Emanuelli
Journal:  Experientia       Date:  1984-07-15

5.  A novel bioaction of PAF: induction of microbicidal activity in guinea pig bone marrow cells.

Authors:  H Hayashi; I Kudo; T Kato; R Nozawa; S Nojima; K Inoue
Journal:  Lipids       Date:  1988-12       Impact factor: 1.880

6.  Inhibition of Paf-acether-induced edema of the rat's paw.

Authors:  K F Swingle; M J Reiter
Journal:  Agents Actions       Date:  1986-06

7.  Kinetics of acetyl glyceryl ether phosphorylcholine (AGEPC)-induced acute lung alterations in the rabbit.

Authors:  L M McManus; R N Pinckard
Journal:  Am J Pathol       Date:  1985-10       Impact factor: 4.307

8.  Effect of platelet-activating factor and serum-treated zymosan on prostaglandin E2 synthesis, arachidonic acid release, and contraction of cultured rat mesangial cells.

Authors:  D Schlondorff; J A Satriano; J Hagege; J Perez; L Baud
Journal:  J Clin Invest       Date:  1984-04       Impact factor: 14.808

9.  Mechanism of action of platelet activating factor in the pulmonary circulation: an investigation using a novel isotopic system in rabbit isolated lung.

Authors:  J P Seale; S Nourshargh; P G Hellewell; T J Williams
Journal:  Br J Pharmacol       Date:  1991-09       Impact factor: 8.739

10.  Experimental model of ischemic bowel necrosis. The role of platelet-activating factor and endotoxin.

Authors:  F Gonzalez-Crussi; W Hsueh
Journal:  Am J Pathol       Date:  1983-07       Impact factor: 4.307
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