| Literature DB >> 6086382 |
G Camussi, G Alloatti, G Montrucchio, M Meda, G Emanuelli.
Abstract
Platelet activating factor (PAF) induces a biphasic effect on guinea-pig papillary muscle: 1. a transient positive inotropic effect preceded by an increase in action potential duration (APD); 2. a marked negative effect on inotropism and on APD. Since Ca++ slow action potentials were initially enhanced by PAF and then markedly depressed, it is suggested that PAF specifically interferes with the Ca++ slow channel.Entities:
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Year: 1984 PMID: 6086382 DOI: 10.1007/bf01949729
Source DB: PubMed Journal: Experientia ISSN: 0014-4754